Nigella Sativa (çörek otu), vitamin C, E ve selenyumun, nitrosoguanidin uygulanan tavşanların tüylerindeki iz element seviyelerine etkileri
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Date
2000
Authors
Mert, Nihat
Ağaoğlu, Zahit T.
Gündüz, Handan
Ertekin, Ali
Dede, Semiha
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Bu çalışmada, Nigella sativa, vitamin C, E ve Se'un, bir karsinojenik madde olan N-methyl-N '-nitro N-nitrosoguanidine (MNNG) uygulanan tavşanların tüylerindeki iz element (Zn, Cu, Mn) konsantrasyonlarına etkileri araştırıldı. Her biri sekizer tavşandan oluşan üç deneme ve bir kontrol grubu oluşturuldu. N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) (20 mg/kg) intraperitonal olarak, beş ay süreyle haftada bir kez uygulandı. Nitrozoguanidin uygulanmasıyla birlikte haftada iki kez, A grubuna öğütülmüş sulu Nigella sativa süspansiyonu, B grubuna Vit C ve Vit E+Se uygulandı. C grubuna ise sadece intraperitonal olarak nitrozoguanidin (20 mg/kg) uygulandı. Kontrol grubu olan D grubuna ise herhangi bir işlem yapılmadı. Gruplardaki (A, B, C, D) tavşanların tüy örneklerinde yapılan analizler sonucunda sırasıyla, çinko konsantrasyonları (ppm); 223.38+7.16, 261.39+9.13, 190.69+2.31 ve 440.11+33.94; bakır konsantrasyonları 30.48+3.94, 65.15+3.35, 8.89+1.93 ve 60.88+2.34; ve manganez konsantrasyonları ise 11.70+2.96, 13.60+1.63, 3.12+0.49 ve 21.13+4.60 olarak saptandı. Gruplar arasında Duncan testine göre, istatistiki olarak anlamlı ilişkiler bulundu. Bu sonuçlara dayanarak, tüy numunelerinin, gruplar arasındaki farkları ortaya koymak açısından önemli bir materyal oldu, Nigella sativa ve vitamin kombinasyonlarının uygulandığı deneme gruplarında, tüy iz element seviyelerinin daha yüksek bulunmasının, nitrosoguanidinin neden olduğu zararlı etkilere karşı koruyucu olarak önemli olabileceğini düşündürmektedir.
In this study, the effect of Nigella sativa, vitamin C, E and Se on the levels of trace element in the rabbit fur treated with N-methyl-N '-nitro-N-nitrosoguanidine (MNNG) were investigated. The rabbit were divided into three experimental groups and one control group, each group contained eight rabbits. N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) (20mg/kg) were administrated intraperitoneally as a carcinogenic compounds. At the same time, it was given Nigella sativa suspension to group A, vit C and vit E +Se combination to group B as preventive material. Group C was only treated by nitrosoguanidin. Group D was control. The Zn, Cu and Mn concentrations of fur samples of groups A, B, C and D were found 223.38+7.16, 261. 39+9.13, 190.69+2.31 and 440.11+33.94; 30.48+3.94, 65.15+3.35, 18.89+1.93 and 60.88+2.34; and 11.70+2.96, 13.60+1.63, 3.12+0.49 and 21.13+4.60 (ppm) respectively. Differences between average values were statistically important. These results suggested that, the levels of trace element of the fur samples are important to determine because of its easy application. As results, the fur trace element concentration of group treated by Nigella sativa and vitamin combination were higher than other groups and it may be useful to observe the positive effects of nitrosoguanidin caused some damage effects.
In this study, the effect of Nigella sativa, vitamin C, E and Se on the levels of trace element in the rabbit fur treated with N-methyl-N '-nitro-N-nitrosoguanidine (MNNG) were investigated. The rabbit were divided into three experimental groups and one control group, each group contained eight rabbits. N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) (20mg/kg) were administrated intraperitoneally as a carcinogenic compounds. At the same time, it was given Nigella sativa suspension to group A, vit C and vit E +Se combination to group B as preventive material. Group C was only treated by nitrosoguanidin. Group D was control. The Zn, Cu and Mn concentrations of fur samples of groups A, B, C and D were found 223.38+7.16, 261. 39+9.13, 190.69+2.31 and 440.11+33.94; 30.48+3.94, 65.15+3.35, 18.89+1.93 and 60.88+2.34; and 11.70+2.96, 13.60+1.63, 3.12+0.49 and 21.13+4.60 (ppm) respectively. Differences between average values were statistically important. These results suggested that, the levels of trace element of the fur samples are important to determine because of its easy application. As results, the fur trace element concentration of group treated by Nigella sativa and vitamin combination were higher than other groups and it may be useful to observe the positive effects of nitrosoguanidin caused some damage effects.
Description
Keywords
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), Tavşan, Tüy, İz element, N.sativa.Vit C.Vit E.Se, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), Rabbit, Fur, Trace element
Citation
Mert, N. vd. (2000). "Nigella Sativa (çörek otu), vitamin C, E ve selenyumun, nitrosoguanidin uygulanan tavşanların tüylerindeki iz element seviyelerine etkileri". Uludağ Üniversitesi Tıp Fakültesi Dergisi, 26(3), 87-90.