Comparative evaluation of galactomannan optical density indices and culture results in bronchoscopic specimens obtained from neutropenic and non-neutropenic patients
dc.contributor.buuauthor | Ağca, Harun | |
dc.contributor.buuauthor | Ener, Beyza | |
dc.contributor.buuauthor | Yılmaz, Emel | |
dc.contributor.buuauthor | Ursavaş, Ahmet | |
dc.contributor.buuauthor | Kazak, Esra | |
dc.contributor.buuauthor | Özkocaman, Vildan | |
dc.contributor.buuauthor | Çetinoǧlu, Ezgi Demirdöǧen | |
dc.contributor.buuauthor | Görek Dilektaşlı, Aslı | |
dc.contributor.buuauthor | Akalın, Halis | |
dc.contributor.buuauthor | Özkalemkaş, Fahir | |
dc.contributor.buuauthor | Ali, Rıdvan | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Verem Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Ünitesi, İç Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-4803-8206 | tr_TR |
dc.contributor.orcid | 0000-0002-2651-2034 | tr_TR |
dc.contributor.orcid | 0000-0002-3894-1231 | tr_TR |
dc.contributor.researcherid | AAG-8523-2021 | tr_TR |
dc.contributor.researcherid | AAH-4027-2021 | tr_TR |
dc.contributor.researcherid | AAU-8952-2020 | tr_TR |
dc.contributor.researcherid | AAI-3169-2021 | tr_TR |
dc.contributor.researcherid | AAH-1854-2021 | tr_TR |
dc.contributor.researcherid | AAG-8459-2021 | tr_TR |
dc.contributor.researcherid | AAG-8495-2021 | tr_TR |
dc.contributor.scopusid | 15759379900 | tr_TR |
dc.contributor.scopusid | 15053025300 | tr_TR |
dc.contributor.scopusid | 22037135100 | tr_TR |
dc.contributor.scopusid | 8329319900 | tr_TR |
dc.contributor.scopusid | 24921238200 | tr_TR |
dc.contributor.scopusid | 6603145040 | tr_TR |
dc.contributor.scopusid | 57189524206 | tr_TR |
dc.contributor.scopusid | 36466376600 | tr_TR |
dc.contributor.scopusid | 57207553671 | tr_TR |
dc.contributor.scopusid | 6601912387 | tr_TR |
dc.contributor.scopusid | 7201813027 | tr_TR |
dc.date.accessioned | 2024-03-05T07:00:44Z | |
dc.date.available | 2024-03-05T07:00:44Z | |
dc.date.issued | 2013-08-10 | |
dc.description.abstract | Aspergillus infections are major causes of morbidity and mortality among immunocompromised patients. This study was designed to investigate the galactomannan assay optical density (OD) indices relative to the culture results in bronchoscopic samples obtained from neutropenic and non-neutropenic patients. Galactomannan OD indices from 1427 samples from 2005 to 2012, which were sent from 839 patients and were composed of bronchial lavage (BL=727) and bronchoalveolar lavage fluids (BAL=700), were retrospectively analysed. The recovery rates of Aspergillus species from these specimens were 9.4% from the combined patient group and 13.3% from the neutropenic group. Aspergillus fumigatus complex was the most frequently isolated species. The mean and median OD indices of the positive and negative culture samples are approximately 5 and 1, respectively, and 91% of all culture-positive samples have 1 OD index value. The receiver-operating characteristics curve analysis demonstrated that the feasibility of the Aspergillus galactomannan assay and Aspergillus galactomannan test has superior accuracy in BAL compared to BL fluids, and the test is not affected by the immune status of the patient. We suggest that the Aspergillus galactomannan test, which uses bronchoscopic material, leads to an earlier diagnosis and if the OD index is found 1, fungal growth can be expected. | en_US |
dc.identifier.citation | Ağca, H. vd. (2013). "Comparative evaluation of galactomannan optical density indices and culture results in bronchoscopic specimens obtained from neutropenic and non-neutropenic patients". Mycoses, 57(3), 169-175. | en_US |
dc.identifier.doi | https://doi.org/10.1111/myc.12126 | en_US |
dc.identifier.eissn | 1439-0507 | |
dc.identifier.endpage | 175 | tr_TR |
dc.identifier.issn | 0933-7407 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.pubmed | 24010950 | tr_TR |
dc.identifier.scopus | 2-s2.0-84893756956 | tr_TR |
dc.identifier.startpage | 169 | tr_TR |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/epdf/10.1111/myc.12126 | en_US |
dc.identifier.uri | https://hdl.handle.net/11452/40195 | en_US |
dc.identifier.volume | 57 | tr_TR |
dc.identifier.wos | 000330886500007 | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | Mycoses | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Aspergillus | en_US |
dc.subject | Galactomannan | en_US |
dc.subject | Culture | en_US |
dc.subject | Invasive pulmonary aspergillosis | en_US |
dc.subject | Bronchoalveolar lavage fluid | en_US |
dc.subject | Hematology | en_US |
dc.subject | Fungal-infections | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Disease | en_US |
dc.subject | Assay | en_US |
dc.subject | Aspergillus | en_US |
dc.subject | Aspergillus galactomannan | en_US |
dc.subject | Aspergillus fumigatus | en_US |
dc.subject | Aspergillus | en_US |
dc.subject | Culture | en_US |
dc.subject | Galactomannan | en_US |
dc.subject | Dermatology | en_US |
dc.subject | Mycology | en_US |
dc.subject.emtree | Accuracy | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Aspergillosis | en_US |
dc.subject.emtree | Aspergillus | en_US |
dc.subject.emtree | Aspergillus fumigatus | en_US |
dc.subject.emtree | Bronchoscopy | en_US |
dc.subject.emtree | Comparative study | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Fiberoptic bronchoscopy | en_US |
dc.subject.emtree | Fungus culture | en_US |
dc.subject.emtree | Fungus growth | en_US |
dc.subject.emtree | Fungus isolation | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human cell | en_US |
dc.subject.emtree | Human tissue | en_US |
dc.subject.emtree | Immune status | en_US |
dc.subject.emtree | Lung lavage | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Neutropenia | en_US |
dc.subject.emtree | Optical density | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Receiver operating characteristic | en_US |
dc.subject.emtree | Retrospective study | en_US |
dc.subject.emtree | Tracheobronchial toilet | en_US |
dc.subject.emtree | Galactomannan | en_US |
dc.subject.mesh | Aspergillosis | en_US |
dc.subject.mesh | Aspergillus fumigatus | en_US |
dc.subject.mesh | Bronchoalveolar lavage fluid | en_US |
dc.subject.mesh | Hematologic neoplasms | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lung diseases, fungal | en_US |
dc.subject.mesh | Mannans | en_US |
dc.subject.mesh | Neutropenia | en_US |
dc.subject.mesh | Retrospective studies | en_US |
dc.subject.mesh | Specimen handling | en_US |
dc.subject.scopus | Invasive Aspergillosis; Mycoses; Systemic Mycosis | en_US |
dc.subject.wos | Dermatology | en_US |
dc.subject.wos | Mycology | en_US |
dc.title | Comparative evaluation of galactomannan optical density indices and culture results in bronchoscopic specimens obtained from neutropenic and non-neutropenic patients | en_US |
dc.type | Article | en_US |
dc.wos.quartile | Q2 | en_US |
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