Yeni kollajen reseptörleri olarak diskoidin domain reseptörleri (ddr’ler) ve önemleri
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Date
2010-10-04
Authors
Reel, Buket
Mıcılı, Serap Cilaker
Ergül, Bekir Uğur
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Ekstraselüler matriks (ESM), hücre ve dokulara destekleyici ve bağlayıcı bir iskelet oluşturur. Aynı zamanda, bileşenleri ile aktive ettiği hücre yüzey reseptörleri aracılığı ile hücreler ve dokular arasındaki iletişimi düzenler. Kollajen, ESM’in temel bileşenlerinden birisidir. Diskoidin Domain Reseptörleri (DDR’ler) farklı tipte kollajenler ile aktive edilen yeni bir tirozin kinaz kollajen reseptör ailesidir. Tirozin kinaz kollajen hücre yüzey reseptörlerinin iki üyesi olan Diskoidin Domain Reseptör 1 ve 2, farklı tipte hücre ve organlarda yaygın bir şekilde eksprese edilir. Bu reseptörler kollajene bağlanarak metalloproteinaz üretimine aracılık ederek hücre adhezyonu, proliferasyonu ve farklılaşmasında esansiyel rol oynarlar. Bu derleme, yeni kollajen reseptörleri hakkındaki mevcut bilgileri özetlemekte ve bu reseptörlerin tümör gelişimi, ateroskleroz, inflamasyon ve fibrozis gibi önemli hastalıklarla ilişkisinin altını çizmektedir. Bu derlemenin DDR’lerin pek çok hastalığın patogenezindeki kompleks rollerinin anlaşılmasına katkı sağlayacağını ve DDR’ler üzerindeki yeni çalışmalara dikkati çekerek bu hastalıkların tedavisine yönelik yeni hedeflerinin oluşturulmasına öncülük edebileceğini umuyoruz.
Extracellular matrix (ECM) provide scaffolding for cells and tissue compartments and also regulate communication between cells and tissues via cell surface receptors which are activated by components of the extracellular matrix. Collagen is one of the the major components of the extracellular matrix (ECM). Discoidin Domain Receptors (DDRs) is a novel family of tyrosine kinase collagen receptors that are activated by several types of collagens. The two members of these cell surface receptors, discoidin domain receptor 1 and 2, are widely expressed in different cell types and organs. DDRs play essential role in regulation of cell adhesion, proliferation and differentiation by binding to collagen and mediating metalloproteinase production. This review article summarizes current knowledge about these new collagen receptors and highlights their relations with crucial diseases such as tumor progression, atherosclerosis, inflammation and tissue fibrosis. We hope, this review may contribute to understanding of their complex roles in the pathogenesis of the wide range of diseases and may draw atraction to new researches on DDRs and lead to establishment of new therapeutical targets for the treatment of these diseases.
Extracellular matrix (ECM) provide scaffolding for cells and tissue compartments and also regulate communication between cells and tissues via cell surface receptors which are activated by components of the extracellular matrix. Collagen is one of the the major components of the extracellular matrix (ECM). Discoidin Domain Receptors (DDRs) is a novel family of tyrosine kinase collagen receptors that are activated by several types of collagens. The two members of these cell surface receptors, discoidin domain receptor 1 and 2, are widely expressed in different cell types and organs. DDRs play essential role in regulation of cell adhesion, proliferation and differentiation by binding to collagen and mediating metalloproteinase production. This review article summarizes current knowledge about these new collagen receptors and highlights their relations with crucial diseases such as tumor progression, atherosclerosis, inflammation and tissue fibrosis. We hope, this review may contribute to understanding of their complex roles in the pathogenesis of the wide range of diseases and may draw atraction to new researches on DDRs and lead to establishment of new therapeutical targets for the treatment of these diseases.
Description
Keywords
Ekstraselüler matriks, Extracellular matrix, Kollajen, Diskoidin domain reseptörler, Collagen, Discoidin domain receptors
Citation
Reel, B. vd. (2010). "Yeni kollajen reseptörleri olarak diskoidin domain reseptörleri (ddr’ler) ve önemleri" Uludağ Üniversitesi Tıp Fakültesi Dergisi, 36(3),121-126.