Obstrüktif uyku apne sendromu progresyonuna etki eden faktörlerin incelenmesi
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Date
2010-12-13
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Uludağ Üniversitesi
Abstract
Obstrüktif uyku apne sendromu (OUAS) üzerine etkili olabilecek etyolojik ve/veya çeşitli komorbid durumların hafiften ağıra doğru giden klinik spektrum üzerindeki yerlerini araştırmaktır. Çalışmaya horlama, gündüz aşırı uyku hali ve yakınları tarafından bildirilen apne semptomlarından bir ya da daha fazlası ile başvuran ve bir gece uyku laboratuvarında yatırılarak tanısal polisomnografi (PSG) yapılan 172 olgu dâhil edildi. Apne hipopne indeksine (AHİ) göre hastalar 4 gruba ayrıldı. Basit horlama hastaları kontrol grubu olarak kabul edildi. Hastalar AHİ değerlerine göre basit horlama 50 (%29.1) , hafif OUAS 38 (%22.1), orta OUAS 43 (%25) ve ağır OUAS 41 (%23.8) olarak gruplandırıldı. Erkek cinsiyet ve vücut kitle indeksi ağır şiddette OUAS grubunda, hipertansiyon ve hiperlipidemi orta şiddette OUAS grubunda istatistiksel açıdan anlamlı olarak fazla saptandı (P <0.05). OUAS şiddetinin ağırlaşmasına vücut kitle indeksi ve diyabetin sinir ve kaslar üzerinde yarattığı fonksiyon bozukluğunun daha etkili olabileceği düşünülmektedir.
The aim of the study is to investigate the impacts of various etiological factors and/or co-morbiities on increasing clinical severity profiles of obstructive sleep apnea syndrome (OSAS). 172 subjects who were admitted with daytime sleepiness and were informed to have at least one of the apnea symptoms and then were undergone to the diagnostic polysomnography procedure. Patients were divided into four subgroups based on their apnea-hypoapnea indices. Simple snoring group was accepted as the control group for comparisons. Simple snoring and mild, moderate and severe OSAS were demonstrated in 50 (29.1%), 38 (22.1%), 43 (25%) and 41 (23.8%) of patients based on AHI values. For severe OSAS male sex and body mass index and for moderate OSAS hypertension and hyperlipidemia were statistically higher based on correlative evaluations (p<0.05). The deteriorating effects of BMI and diabetes on functions of nerves and muscles could be considered to be responsible of the increasing severity of OSAS
The aim of the study is to investigate the impacts of various etiological factors and/or co-morbiities on increasing clinical severity profiles of obstructive sleep apnea syndrome (OSAS). 172 subjects who were admitted with daytime sleepiness and were informed to have at least one of the apnea symptoms and then were undergone to the diagnostic polysomnography procedure. Patients were divided into four subgroups based on their apnea-hypoapnea indices. Simple snoring group was accepted as the control group for comparisons. Simple snoring and mild, moderate and severe OSAS were demonstrated in 50 (29.1%), 38 (22.1%), 43 (25%) and 41 (23.8%) of patients based on AHI values. For severe OSAS male sex and body mass index and for moderate OSAS hypertension and hyperlipidemia were statistically higher based on correlative evaluations (p<0.05). The deteriorating effects of BMI and diabetes on functions of nerves and muscles could be considered to be responsible of the increasing severity of OSAS
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Keywords
Obstrüktif uyku apne sendromu, Obstructive sleep apnea, Apne hipopne indeksi, Vücut kitle indeksi, Diyabet, Apnea hypopnea index, Body mass index, Diabetes
Citation
Yıldız, A. vd. (2010). "Obstrüktif uyku apne sendromu progresyonuna etki eden faktörlerin incelenmesi" Uludağ Üniversitesi Tıp Fakültesi Dergisi, 36(3),81-84.