In vitro pharmacodynamics of a danofloxacin plus colistin combination against multidrug-resistant (MDR) Escherichia coli isolated from animals

Basit Görünüm
dc.contributor.buuauthorCengiz, Murat
dc.contributor.buuauthorŞahintürk, Pınar
dc.contributor.buuauthorHepbostancı, Gülce
dc.contributor.buuauthorAkalın, Halis
dc.contributor.buuauthorSonal, Songül
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-7601-7640tr_TR
dc.contributor.orcid0000-0002-4208-4025tr_TR
dc.contributor.orcid0000-0003-4346-5337tr_TR
dc.contributor.orcid0000-0001-7530-1279tr_TR
dc.contributor.orcid0000-0001-9018-1842tr_TR
dc.date.accessioned2020-12-22T08:35:02Z
dc.date.available2020-12-22T08:35:02Z
dc.date.issued2019-09-23
dc.description.abstractAs an alternative antimicrobial combination, danofloxacin+colistin was used for the inhibition of multidrug resistant E.coli. After evaluation of interaction between the drugs by fractional inhibitory concentration tests and time kill assays, antimicrobial activity of the combination was showed by in vitro pharmacodynamics tests (minimum bactericidal concentration and mutant prevention concentration). Post-antibiotic and post-antibiotic sub-MIC effects were also determined in this study. In synergism tests, danofloxacin+colistin was found highly synergistic (%87) against E.coli isolates from animal origin. The combination exerted bactericidal activity against all E.coli isolates and individual bactericidal activity of each compound was lower than the combination. The combination reduced mutant prevention concentration of danofloxacin and colistin up to 32 –fold. Post-antibiotic sub-MIC effects of the combination at all sub-MIC concentrations were significantly longer than the post-antibiotic effects of combination (p < 0.001), danofloxacin (p < 0.001) and colistin (p < 0.001). The results of this study showed that danofloxacin+colistin combination can be reserved as an alternative drug combination against MDR E.coli in veterinary medicine.en_US
dc.identifier.citationCengiz, M. vd. (2019). "In vitro pharmacodynamics of a danofloxacin plus colistin combination against multidrug-resistant (MDR) Escherichia coli isolated from animals". Bursa Uludağ Üniversitesi Veteriner Fakültesi, 38(2), 24-30.tr_TR
dc.identifier.endpage30tr_TR
dc.identifier.issn1301-3173
dc.identifier.issue2tr_TR
dc.identifier.startpage24tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/891650
dc.identifier.urihttp://hdl.handle.net/11452/14536
dc.identifier.volume38tr_TR
dc.language.isoenen_US
dc.publisherBursa Uludağ Üniversitesitr_TR
dc.relation.journalVeteriner Hekimlikte Araştırma Dergisi / Journal of Research in Veterinary Medicinetr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak(TOVAG110O478, BIDEB-2211)tr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColistinen_US
dc.subjectDanofloxacinen_US
dc.subjectIn vitro pharmacodynamicsen_US
dc.subjectMDR. E.en_US
dc.titleIn vitro pharmacodynamics of a danofloxacin plus colistin combination against multidrug-resistant (MDR) Escherichia coli isolated from animalsen_US
dc.typeArticleen_US

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2019 Cilt 38 Sayı 2