Declines in serum free and bound choline concentrations in humans after three different types of major surgery

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dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorUncu, Gürkan
dc.contributor.buuauthorGören, Suna
dc.contributor.buuauthorSayan, Erkan
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1190-6831tr_TR
dc.contributor.orcid0000-0003-3943-5549tr_TR
dc.contributor.researcheridAAI-3551-2021tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid6603716169tr_TR
dc.contributor.scopusid7006563257tr_TR
dc.contributor.scopusid6506894833tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.date.accessioned2022-04-27T05:59:12Z
dc.date.available2022-04-27T05:59:12Z
dc.date.issued2004
dc.description.abstractWe examined the changes in circulating choline status in humans in response to major surgery by measuring serum free and phospholipid-bound choline concentrations before, during and 1-72 h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery. Preoperatively, the mean serum free and phospholipid-bound choline concentrations in patients scheduled for abdominal hysterectomy (n=26), off-pump coronary artery grafting surgery (n=34) or brain tumor surgery (n=24) were 12.3+/-0.5, 12.1+/-0.4 and 11.4+/-0.4 mumol/l, and 2495+/-75, 2590+/-115 and 2625+/-80 mumol/l, respectively. Serum free choline and phospholipid-bound choline concentrations decreased from these baseline values to 8.8+/-0.7 (p<0.001), 8.8 +/- 0.5 (p<0.001) and 8.2+/-0.4 mumol/l (p<0.001), and 2050 +/- 108 (p<0.001), 2166+/-59 (p<0.001) and 1884 +/- 104 mu mol/l (p<0.001) at 1 h after hysterectomy, off-pump bypass graft surgery or brain tumor surgery, respectively. They remained at these low levels for 24 h and then gradually increased towards the preoperative values at 48-72 h postoperatively. Serum cortisol increased postoperatively in all surgical patients for 24 h and its levels were inversely correlated with serum free and bound choline concentrations. These results show that circulating free and bound choline concentrations decrease for 72 h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery in humans.en_US
dc.identifier.citationİlçöl, Y. Ö. vd. (2004). “Declines in serum free and bound choline concentrations in humans after three different types of major surgery”. Clinical Chemistry and Laboratory Medicine, 42(12), 1390-1395.en_US
dc.identifier.endpage1395tr_TR
dc.identifier.issn1434-6621
dc.identifier.issue12tr_TR
dc.identifier.pubmed15576301tr_TR
dc.identifier.scopus2-s2.0-11244302453tr_TR
dc.identifier.startpage1390tr_TR
dc.identifier.urihttps://doi.org/10.1515/CCLM.2004.259
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/CCLM.2004.259/html
dc.identifier.urihttp://hdl.handle.net/11452/26131
dc.identifier.volume42tr_TR
dc.identifier.wos000225906600007tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyterde
dc.relation.journalClinical Chemistry and Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedical laboratory technologyen_US
dc.subjectBound cholineen_US
dc.subjectBrain surgeryen_US
dc.subjectCortisolen_US
dc.subjectFree cholineen_US
dc.subjectHysterectomyen_US
dc.subjectSurgical stressen_US
dc.subjectTyrosine-hydroxylaseen_US
dc.subjectAcetylcholine-releaseen_US
dc.subjectEssential nutrienten_US
dc.subjectPlasma cholineen_US
dc.subjectRaten_US
dc.subjectBrainen_US
dc.subjectMechanismsen_US
dc.subjectIncreasesen_US
dc.subjectDecreaseen_US
dc.subjectInductionen_US
dc.subject.emtreeAbdominal hysterectomyen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood levelen_US
dc.subject.emtreeBrain surgeryen_US
dc.subject.emtreeBrain tumoren_US
dc.subject.emtreeCirculationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation functionen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMajor surgeryen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeOff pump coronary surgeryen_US
dc.subject.emtreePostoperative perioden_US
dc.subject.emtreePreoperative perioden_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeStatistical analysisen_US
dc.subject.emtreeSurgical patienten_US
dc.subject.emtreeCholineen_US
dc.subject.emtreePhospholipiden_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBrain neoplasmsen_US
dc.subject.meshCholineen_US
dc.subject.meshCoronary artery bypassen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrocortisoneen_US
dc.subject.meshHysterectomyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeurosurgical proceduresen_US
dc.subject.meshPhospholipidsen_US
dc.subject.meshTime factorsen_US
dc.subject.meshUterine neoplasmsen_US
dc.subject.scopusCholine; Dimethylglycine; Pregnancyen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleDeclines in serum free and bound choline concentrations in humans after three different types of major surgeryen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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