Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs
dc.contributor.buuauthor | İlçöl, Yeşim Özarda | |
dc.contributor.buuauthor | Yılmaz, Zeki | |
dc.contributor.buuauthor | Ulus, İsmail Hakkı | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-9836-0749 | tr_TR |
dc.contributor.researcherid | AAL-8873-2021 | tr_TR |
dc.contributor.researcherid | D-5340-2015 | tr_TR |
dc.contributor.researcherid | A-9637-2008 | tr_TR |
dc.contributor.scopusid | 35741320500 | tr_TR |
dc.contributor.scopusid | 35944810500 | tr_TR |
dc.contributor.scopusid | 7004271086 | tr_TR |
dc.date.accessioned | 2022-04-28T11:06:46Z | |
dc.date.available | 2022-04-28T11:06:46Z | |
dc.date.issued | 2003-03-27 | |
dc.description.abstract | We designed this study to determine whether serum free and phospholipid-bound choline concentrations change after surgery or methylprednisolone treatment in dogs and rats. In dogs, serum free and phospholipid-bound choline concentrations were decreased by 29% and 17% immediately after abdominal-pelvic surgery under xylasine + ketamine anesthesia, respectively, and both remained low for 24 h. Serum cortisol was elevated after surgery. The elevation in serum cortisol was inversely correlated with the decreases in free (r = -0.737; P < 0.001) and phospholipid-bound (r = -0.771; P < 0.001) choline concentrations. After methyprednisolone administration (5-20 mg/kg) free and phospholipid-bound choline concentrations decreased in a dose- and time-dependent manner. In rats, either surgery or methylprednisolone failed to alter serum free choline concentrations while phospholipid-bound choline decreased after surgery. These data show that the decrease in serum choline after surgery results from the increase in circulating glucocorticoids. | en_US |
dc.identifier.citation | İlçöl, Y. Ö. vd. (2003). “Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs”. Neuroscience Letters, 339(3), 195-198. | en_US |
dc.identifier.endpage | 198 | tr_TR |
dc.identifier.issn | 0304-3940 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.pubmed | 12633886 | tr_TR |
dc.identifier.scopus | 2-s2.0-0037468578 | tr_TR |
dc.identifier.startpage | 195 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/S0304-3940(03)00035-1 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0304394003000351 | |
dc.identifier.uri | http://hdl.handle.net/11452/26237 | |
dc.identifier.volume | 339 | tr_TR |
dc.identifier.wos | 000181641600006 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.journal | Neuroscience Letters | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Neurosciences and neurology | en_US |
dc.subject | Free choline | en_US |
dc.subject | Phospholipid-bound choline | en_US |
dc.subject | Stress | en_US |
dc.subject | Glucocorticoid | en_US |
dc.subject | Dog | en_US |
dc.subject | Methylprednisolone | en_US |
dc.subject | Cortisol | en_US |
dc.subject | Acetylcholine | en_US |
dc.subject | Stress | en_US |
dc.subject.emtree | Abdominal surgery | en_US |
dc.subject.emtree | Anesthesia | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Blood analysis | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dog | en_US |
dc.subject.emtree | Dose time effect relation | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Hydrocortisone blood level | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Pelvis surgery | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Hydrocortisone | en_US |
dc.subject.emtree | Ketamine | en_US |
dc.subject.emtree | Methylprednisolone | en_US |
dc.subject.emtree | Phospholipid | en_US |
dc.subject.emtree | Xylazine | en_US |
dc.subject.scopus | Choline; Dimethylglycine; Pregnancy | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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