Susceptibility of apolipoprotein B-containing lipoproteins to oxidation and antioxidant status in acute coronary syndromes

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dc.contributor.buuauthorYeşilbursa, Dilek
dc.contributor.buuauthorSerdar, Zehra
dc.contributor.buuauthorDirican, Melahat
dc.contributor.buuauthorSerdar, Akın
dc.contributor.buuauthorGüllülü, Sümeyye
dc.contributor.buuauthorCordan, Jale
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-6985-2021tr_TR
dc.date.accessioned2021-09-14T07:28:00Z
dc.date.available2021-09-14T07:28:00Z
dc.date.issued2000
dc.description.abstractBackground: Oxidized lipoproteins may play an important role in the pathogenesis of atherosclerosis, and it has been shown that antioxidants have a protective effect against the progression of atherosclerosis. Hypothesis: The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B-containing lipoproteins and antioxidant status in patients with acute coronary syndromes and chronic stable angina pectoris. Methods: The study population included 70 patients with acute coronary syndromes (14 with recent acute myocardial infarction and 56 with unstable angina pectoris), 105 patients with stable angina pectoris, and 75 control subjects. In addition to conventional lipid and lipoprotein analysis, the susceptibility of apolipoprotein B-containing lipoproteins to in vitro oxidation (lag phase) and plasma vitamin E and total carotene levels was measured. Results: The lag phase was significantly shorter in patients with acute coronary syndromes (45 +/- 12 min) than in patients with stable angina pectoris (51 +/- 10 min) and in control subjects (58 +/- 9 min) (p < 0.0001). Both plasma vitamin E and total carotene levels were lowest in patients with acute coronary syndromes (1.11 +/- 0.32 mg/dl and 119 +/- 32 mu g/dl, respective ly), followed by patients with stable angina pectoris (1.25 +/- 0.37 mg/dl and 132 +/- 37 mu g/dl) and then controls (1.52 +/- 0.31 mg/dl and 167 +/- 41 mu g/dl). Conclusions: These data suggest that there is an intense oxidative process and a lower antioxidant status in acute coronary syndromes. This may lead to plaque instability due to the activation of the inflammatory response in coronary atherosclerotic lesions.en_US
dc.identifier.citationYeşilbursa, D. vd. (2000). "Susceptibility of apolipoprotein B-containing lipoproteins to oxidation and antioxidant status in acute coronary syndromes". Clinical Cardiology, 23(9), 655-658.en_US
dc.identifier.endpage658tr_TR
dc.identifier.issn0160-9289
dc.identifier.issue9tr_TR
dc.identifier.pubmed11016014tr_TR
dc.identifier.scopus2-s2.0-0033805203tr_TR
dc.identifier.startpage655tr_TR
dc.identifier.urihttps://doi.org/10.1002/clc.4960230905
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655178/
dc.identifier.urihttp://hdl.handle.net/11452/21924
dc.identifier.volume23tr_TR
dc.identifier.wos000089305600004tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalClinical Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subjectLipoprotein oxidationen_US
dc.subjectAntioxidantsen_US
dc.subjectAcute coronary syndromesen_US
dc.subjectStable coronary artery diseaseen_US
dc.subjectLow-density-lipoproteinen_US
dc.subjectLipid oxidationen_US
dc.subjectHeart-diseaseen_US
dc.subjectVitamin-Een_US
dc.subjectAtherosclerosisen_US
dc.subjectAtherogenesisen_US
dc.subjectCholesterolen_US
dc.subjectPlasmaen_US
dc.subjectLDLen_US
dc.subject.scopusLow Density Lipoprotein; Peroxidation; Atherogenesisen_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.titleSusceptibility of apolipoprotein B-containing lipoproteins to oxidation and antioxidant status in acute coronary syndromesen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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