İntravenöz anesteziklerin sistemik vasküler rezistans üzerine etkileri
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Date
2000
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Publisher
Uludağ Üniversitesi
Abstract
Elektif koroner arter bypass cerrahisi uygulanacak 62 olguda tiyopental sodyum (Grup T; n=20), propofol (Gıup P; n=22) ve etomidatın (Grup E; n=20), hipotermik kardiyopulmoner bypass sırasında perfüzyon akımı sabit iken perfüzyon basıncı ve sistemik vasküler rezistans (SVR) olan etkilerini araştırdık. 10 dakikalık takip süresince ortalama arter basıncı (MAP) ve rezervuar volümünde meydana gelen maksimum değişiklikler kaydedildi. SVR hesaplandı. Grup P de daha fazla olmak üzere, her 3 grupta da MAP da anlamlı düşme saptanmıştır (Grup T, Grup P, Grup E'de sırasıyla p<0.05, p<0.001, p<0.05). Fakat SVR da her üç grup arasında anlamlı bir değişiklik gözlenmemiştir. Sonuç olarak, KPB sırasında propofol grubunda daha belirgin olmak üzere her üç iv anestezik ajan perfüzyon basıncı ve SVR'da benzer değişiklikler meydana getirmiştir.
We studied the effects of thiopentale sodium (Group T; n=20), propofol (Group P; n=22) and etomidate (Group E; n=20) on perfusion pressure and systemic vascular resistance (SVR) during hypothermic cardiopulmonary bypass with constant pump flow in 62 patients undergoing elective coronary artery bypass surgery. The maximal changes in mean arterial pressure (MAP) and reservoir volume were recorded during a 10 minutes period and systemic vascular resistance was calculated. The decrease in MAP was signifıcant in all groups, especially in Group P (Group T, Group P, Group E, respectively p<0.05, p<0.001, p<0,05). But there were no significant differences in the changes SVR between the groups. As a result, all three iv anesthetic agents, have similar effects on perfusion pressure and SVR during CPB, but the changes with propofol were more signifıcant.
We studied the effects of thiopentale sodium (Group T; n=20), propofol (Group P; n=22) and etomidate (Group E; n=20) on perfusion pressure and systemic vascular resistance (SVR) during hypothermic cardiopulmonary bypass with constant pump flow in 62 patients undergoing elective coronary artery bypass surgery. The maximal changes in mean arterial pressure (MAP) and reservoir volume were recorded during a 10 minutes period and systemic vascular resistance was calculated. The decrease in MAP was signifıcant in all groups, especially in Group P (Group T, Group P, Group E, respectively p<0.05, p<0.001, p<0,05). But there were no significant differences in the changes SVR between the groups. As a result, all three iv anesthetic agents, have similar effects on perfusion pressure and SVR during CPB, but the changes with propofol were more signifıcant.
Description
Bu çalışma, Ekim 1997 tarihinde Bursa[Türkiye]'da düzenlenen V. Göğüs Kalp Damar Anestezi ve Yoğun Bakım Kongresi'nde bildiri olarak sunulmuştur.
Keywords
IV anestezikler, Kardiyopulmoner by-pass, Sistemik vasküler rezistans, IV anesthetics, Cardiopulmonary bypass, Systemic vascular resistance
Citation
Gören, S. vd. (1999-2000). ''İntravenöz anesteziklerin sistemik vasküler rezistans üzerine etkileri''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 26(1-2-3/1-2), 47-50.