The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study

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dc.contributor.buuauthorNoyan, Semiha
dc.contributor.buuauthorÇavuşoğlu, İlkin
dc.contributor.buuauthorMinbay, F. Zehra
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-5757-8450tr_TR
dc.contributor.researcheridABC-1475-2020tr_TR
dc.contributor.scopusid56636269700tr_TR
dc.contributor.scopusid56009155800tr_TR
dc.contributor.scopusid12040872100tr_TR
dc.date.accessioned2021-10-07T06:07:56Z
dc.date.available2021-10-07T06:07:56Z
dc.date.issued2006
dc.description.abstractIn this study, we aimed to investigate the effect of vitamin A on the transformation of the Ito cells to fibrogenic form and suppression of the development of fibrosis. Carbon tetrachloride intoxication was performed on rats for 2, 8, 12 or 20 weeks and 5 x 10(4) IU vitamin A (as retinol palmitate) was injected subcutaneously once every 4 weeks. Ito cells were detected by gold chloride impregnation, as well as desmin and alpha-smooth muscle actin (alpha-SMA) immunohistochemistry. Additionally, all groups were examined ultrastructurally. The number of Ito cells that were labelled positively with gold impregnation decreased in the fibrotic groups; however, alpha-SMA and desmin immunopositive Ito cells increased. The samples from animals that were treated with vitamin A showed an increase in labelling with gold impregnation but a decrease in alpha-SMA immunopositivity. The data showed that vitamin A can prevent hepatic injury, by suppressing the transformation of Ito cells to fibrogenic form. We conclude that vitamin A has potential for the treatment of hepatic fibrotic diseases. alpha-SMA immunohistochemistry was found to be more informative than desmin immunohistochemistry for monitoring Liver fibrosis.en_US
dc.identifier.citationNoyan, S. vd. (2006). ''The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study''. Acta Histochemica, 107(6), 421-434.en_US
dc.identifier.endpage431tr_TR
dc.identifier.issn0065-1281
dc.identifier.issue6tr_TR
dc.identifier.pubmed16256175tr_TR
dc.identifier.scopus2-s2.0-31544436592tr_TR
dc.identifier.startpage421tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2005.09.001
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0065128105000838
dc.identifier.urihttp://hdl.handle.net/11452/22258
dc.identifier.volume107tr_TR
dc.identifier.wos000235733600002tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.journalActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell biologyen_US
dc.subjectIto cellsen_US
dc.subjectVitamin Aen_US
dc.subjectDesminen_US
dc.subjectAlpha-smooth muscle actinen_US
dc.subjectAlpha-SMAen_US
dc.subjectFibrosisen_US
dc.subjectCollagen typesen_US
dc.subjectTransitional cellen_US
dc.subjectExtracellular-matrixen_US
dc.subjectPerisinusoidal cellsen_US
dc.subjectCarbon-tetrachlorideen_US
dc.subjectSmooth-muscle-actinen_US
dc.subjectAlcoholic liver-injuryen_US
dc.subjectFat-storing cellsen_US
dc.subjectAnimaliaen_US
dc.subjectLiving systems studiesen_US
dc.subjectImpregnationen_US
dc.subjectGolden_US
dc.subjectDiseasesen_US
dc.subjectCarbon inorganic compoundsen_US
dc.subjectCell cultureen_US
dc.subjecta-SMAen_US
dc.subjecta-smooth muscle actinen_US
dc.subjectVitaminsen_US
dc.subject.emtreeGold derivativeen_US
dc.subject.emtreeSmooth muscle actinen_US
dc.subject.emtreeRetinolen_US
dc.subject.emtreeDesminen_US
dc.subject.emtreeAntioxidanten_US
dc.subject.emtreeActinen_US
dc.subject.emtreeRetinolen_US
dc.subject.emtreeGold chlorideen_US
dc.subject.emtreeDesminen_US
dc.subject.emtreeCarbon tetrachlorideen_US
dc.subject.emtreeAlpha smooth muscle actinen_US
dc.subject.emtreeWistar raten_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeLiver cirrhosisen_US
dc.subject.emtreeLiver cellen_US
dc.subject.emtreeElectron microscopyen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeCytochemistryen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeChemically induced disorderen_US
dc.subject.emtreeCell proliferationen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeUltrastructureen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeMicroscopyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeLiver injuryen_US
dc.subject.emtreeLiver fibrosisen_US
dc.subject.emtreeLto cellen_US
dc.subject.emtreeIntoxicationen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeHstopathologyen_US
dc.subject.emtreeHistochemistryen_US
dc.subject.emtreeFibrosisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.meshVitamin Aen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshRatsen_US
dc.subject.meshMicroscopy, electronen_US
dc.subject.meshMaleen_US
dc.subject.meshLiver cirrhosisen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshHepatocytesen_US
dc.subject.meshGold compoundsen_US
dc.subject.meshDesminen_US
dc.subject.meshCell proliferationen_US
dc.subject.meshCarbon tetrachlorideen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshActinsen_US
dc.subject.scopusHepatic Stellate Cells; Liver Fibrosis; Thioacetamideen_US
dc.subject.wosCell biologyen_US
dc.titleThe effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural studyen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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