Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well

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dc.contributor.buuauthorGüllülü, Mustafa
dc.contributor.buuauthorAkdağ, İbrahim
dc.contributor.buuauthorKahvecioğlu, Serdar
dc.contributor.buuauthorFiliz, Gülaydan
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.date.accessioned2021-09-29T12:18:57Z
dc.date.available2021-09-29T12:18:57Z
dc.date.issued2006
dc.description.abstractStudies performed recently have determined that aldosterone has not only a major role in electrolyte and water balance and K excretion, but it also modulates myofibroblast growth in the heart and blood vessels and causes fibrosis. This study investigated the effects of aldosterone blockers in rats with anti-thy 1.1 nephritis, both on proliferation and fibrosis, by comparing it to an angiotensin receptor inhibitor valsartan. Rats with anti-thy 1.1 nephritis were randomly allocated to one of the three following groups of treatment: the control group ( group 1); those treated with the aldosterone receptor blocker spironolactone ( group 2); and those treated with the ATRB valsartan ( group 3). On day 7, the parameters of glomerular fibrosis [ transforming growth factor beta, TGF staining areas %], proliferation (Ki-67), and renal damage scores were determined. The TGF-beta and Ki-67 levels of control group were significantly more than the other two groups (p < 0.01). The TGF staining areas percentages were significantly decreased compared to control group. The artery, glomerular, and renal injury scores evaluated between the groups were found to be significantly decreased compared to control group. In line with previous studies, this study found that in anti-thy 1.1 mesangioproliferative glomerulonephritis, aldosterone blockage affected proliferation and fibrosis.en_US
dc.identifier.citationGüllülü, M. vd. (2006). ''Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well''. Renal Failure, 28(6), 509-514.en_US
dc.identifier.endpage514tr_TR
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue6tr_TR
dc.identifier.pubmed16928621tr_TR
dc.identifier.scopus2-s2.0-33747804321tr_TR
dc.identifier.startpage509tr_TR
dc.identifier.urihttps://doi.org/10.1080/08860220600779033
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/08860220600779033
dc.identifier.urihttp://hdl.handle.net/11452/22143
dc.identifier.volume28tr_TR
dc.identifier.wos000239966600010tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrology & nephrologyen_US
dc.subjectGlomerulosclerosisen_US
dc.subjectAT receptor blockeren_US
dc.subjectAldosterone antagonismen_US
dc.subjectKi-67en_US
dc.subjectAnti-thy 1.1en_US
dc.subjectTGF betaen_US
dc.subjectInhibitionen_US
dc.subjectProgressionen_US
dc.subjectNephropathyen_US
dc.subjectHypertensionen_US
dc.subjectNephrosclerosisen_US
dc.subjectDamageen_US
dc.subjectProteinuriaen_US
dc.subjectSpironolactoneen_US
dc.subjectRenal-diseaseen_US
dc.subjectAngiotensin-IIen_US
dc.subject.scopusMineralocorticoid Antagonist; BAY 94-8862; Eplerenoneen_US
dc.subject.wosUrology & nephrologyen_US
dc.titleAldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as wellen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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