Different neuroendocrine profiles of remitted and nonremitted schizophrenic patients

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dc.contributor.authorYazıcı, Kezban
dc.contributor.authorYazıcı, Aylin Ertekin
dc.contributor.buuauthorTaneli, Bilgen
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Bölümü.tr_TR
dc.contributor.scopusid6603520984tr_TR
dc.date.accessioned2021-09-01T11:22:10Z
dc.date.available2021-09-01T11:22:10Z
dc.date.issued2002-04
dc.description.abstractBackground: Thyrotropin-releasing hormone (TRH) test and Dexamethasone Suppression Test (DST) are two neuroendocrine tests that have been extensively used in an attempt to predict treatment response and outcome in schizophrenia. The objectives of this study were to investigate (1) the relationship between TRH test and DST and various psychiatric symptoms and (2) the potential value of these tests in prediction of short-term outcome in schizophrenic patients. Methods: TRH test and DST were administered to 58 patients with schizophrenia. All patients were evaluated with a battery of rating scales before neuroendocrine test procedures and at regular intervals for I year. Patients were divided into two groups as remitted (RP; n = 30) and nonremitted patients (NRP; n = 28). Baseline results of these two groups were compared with each other and 30 healthy controls. Results: Basal levels of total T-3 (T-3T) and free T-3 (T-3F) were higher in RP group than controls. Basal prolactin (PRL) level was higher in R-P group, but not in NRP, compared to controls. Basal growth hormone (GH) and thyroidstimulating hormone (TSH) levels of NRP were significantly higher than those of RP. DST nonsuppression was observed at a significantly higher rate in RP than NRP and control group. Blunted TSH response rate in RP group was higher significantly compared to other two groups. Conclusions: The data implicate that higher basal TSH and GH levels may be associated with a poorer treatment response, whereas higher total and free T3 levels, a blunted TSH response to TRH and nonsuppression on the DST may indicate a better response in schizophrenics.en_US
dc.identifier.citationYazıcı, K. vd. (2002). "Different neuroendocrine profiles of remitted and nonremitted schizophrenic patients". Progress In Neuro-Psychopharmacology & Biological Psychıatry, 26(3), 579-584.en_US
dc.identifier.endpage584tr_TR
dc.identifier.issn0278-5846
dc.identifier.issue3tr_TR
dc.identifier.pubmed11999911tr_TR
dc.identifier.scopus2-s2.0-0036197150tr_TR
dc.identifier.startpage579tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0278-5846(01)00311-6
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0278584601003116
dc.identifier.urihttp://hdl.handle.net/11452/21605
dc.identifier.volume26tr_TR
dc.identifier.wos000174698300023tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosSSCIen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.collaborationYurtiçitr_TR
dc.relation.journalProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTRH testen_US
dc.subjectDepressionen_US
dc.subjectDSTen_US
dc.subjectOutcomeen_US
dc.subjectPsychoneuroendocrinologyen_US
dc.subjectRemissionen_US
dc.subjectSchizophreniaen_US
dc.subjectDexamethasone suppression testen_US
dc.subjectThyrotropin-releasing-hormoneen_US
dc.subjectThyroid-functionen_US
dc.subjectPsychiatric-patientsen_US
dc.subjectAxis hyperactivity negativeen_US
dc.subjectSymptomsen_US
dc.subjectTsh-responseen_US
dc.subjectTRHen_US
dc.subjectDisorderen_US
dc.subjectNegative symptompsen_US
dc.subject.scopusHyperthyroidism; Myxedema; Levothyroxine Sodiumen_US
dc.subject.wosNeurosciences & neurologyen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.subject.wosPsychiatryen_US
dc.subject.wosClinical neurologyen_US
dc.titleDifferent neuroendocrine profiles of remitted and nonremitted schizophrenic patientsen_US
dc.typeReview
dc.wos.quartileQ2 (Clinical Neurology)en_US
dc.wos.quartileQ3en_US

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