Importance of glycogen phosphorylase isoenzyme BB, total sialic acid, oxidant and antioxidant parameters in the noninvasive assessment of thrombolytic therapy

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dc.contributor.buuauthorSerdar, Zehra
dc.contributor.buuauthorAltın, Aysun
dc.contributor.buuauthorSerdar, Akın
dc.contributor.buuauthorBilgili, Gökhan
dc.contributor.buuauthorDoğruk, Elif Emre
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0909-618Xtr_TR
dc.contributor.researcheridAAH-6200-2021tr_TR
dc.contributor.scopusid57222002284tr_TR
dc.contributor.scopusid17134032300tr_TR
dc.contributor.scopusid6603403111tr_TR
dc.contributor.scopusid35077543700tr_TR
dc.contributor.scopusid55355828300tr_TR
dc.date.accessioned2022-04-07T06:47:41Z
dc.date.available2022-04-07T06:47:41Z
dc.date.issued2012
dc.description.abstractObjective: The aim of this study was to investigate the effect of thrombolytic therapy on oxidant and antioxidant parameters and glycogen phosphorylase isoenzyme BB (GPBB) concentrations in patients with acute myocardial infarction (AMI). Material and Method: This was a prospective study at an urban academic hospital. We enrolled non-traumatized patients arriving at the emergency department within 3 hours after the onset of chest pain suggestive of AMI. The diagnosis of AMI was established according to clinical features, electrocardiographic findings and increased biochemistry cardiac marker levels. The study was carried out on a total of 75 patients with AMI (50 patients received thrombolytic therapy and 25 patients did not receive thrombolytic therapy), and 45 controls. Blood samples were collected before, and, 2 and 24 hours after tissue-type plasminogen activator therapy Serum malondialdehyde (MDA) and vitamin E were analyzed by high-performance liquid chromatography. Serum total sialic acid and other oxidant and antioxidant parameters were studied spectrophotometrically. Determination of GPBB concentration is based on immunoenzymometric assay. Results: Successful reperfusion was followed by increased serum MDA, protein carbonyls, total sialic acid and GPBB concentrations and by decreased antioxidant vitamins and enzymes. Conclusion: These findings indicate the significance free radical generation processes in reperfusion injury in AMI patients, and suggest the potential involvement of antioxidants in the management of AMI treated by thrombolysis. Also, these parameters especially GPBB can be used for the noninvasive assessment of the effectiveness of thrombolytic therapy.en_US
dc.identifier.citationSerdar, Z. vd. (2012). "Importance of glycogen phosphorylase isoenzyme BB, total sialic acid, oxidant and antioxidant parameters in the noninvasive assessment of thrombolytic therapy". Nobel Medicus, 8(3), 32-39.tr_TR
dc.identifier.endpage39tr_TR
dc.identifier.issn1305-2381
dc.identifier.issue3tr_TR
dc.identifier.scopus2-s2.0-84872975642tr_TR
dc.identifier.startpage32tr_TR
dc.identifier.urihttps://www.nobelmedicus.com/Content/1/24/32-39.pdf
dc.identifier.urihttp://hdl.handle.net/11452/25619
dc.identifier.volume8tr_TR
dc.identifier.wos000312928700006tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherNobel İlaçtr_TR
dc.relation.journalNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectThrombolytic therapyen_US
dc.subjectGlycogen phosphorylase isoenzyme bben_US
dc.subjectSialic aciden_US
dc.subjectParaoxonaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectSerum paraoxonase arylesteraseen_US
dc.subjectCoronary-heart-diseaseen_US
dc.subjectVitamin-een_US
dc.subjectLipid-peroxidationen_US
dc.subjectOxidative stressen_US
dc.subjectPlasma malondialdehydeen_US
dc.subjectCardiovascular-diseaseen_US
dc.subjectMyocardial-ischemiaen_US
dc.subjectBiochemical markersen_US
dc.subjectTroponin-ten_US
dc.subject.emtreeAlpha tocopherolen_US
dc.subject.emtreeAlteplaseen_US
dc.subject.emtreeFibrinolytic agenten_US
dc.subject.emtreeGlycogen phosphorylase ben_US
dc.subject.emtreeGlycogen phosphorylase isoenzyme bben_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeSialic aciden_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAcute heart infarctionen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood clot lysisen_US
dc.subject.emtreeCardiovascular risken_US
dc.subject.emtreeDisease markeren_US
dc.subject.emtreeElectrocardiographyen_US
dc.subject.emtreeEmergency warden_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFibrinolytic therapyen_US
dc.subject.emtreeHigh performance liquid chromatographytren_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNon invasive procedureen_US
dc.subject.emtreePharmacological parametersen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeThorax painen_US
dc.subject.scopusSialic Acids; Glycoconjugates; Fucoseen_US
dc.subject.wosMedicine, general & internalen_US
dc.titleImportance of glycogen phosphorylase isoenzyme BB, total sialic acid, oxidant and antioxidant parameters in the noninvasive assessment of thrombolytic therapyen_US
dc.typeArticle

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