Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo

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dc.contributor.authorDimas, Konstantinos
dc.contributor.authorİkitimur, Elif İlkay
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorYılmaz, Veysel T.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.tr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.orcid0000-0002-2849-3332tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.researcheridL-7238-2018tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.contributor.scopusid24376085300tr_TR
dc.contributor.scopusid7006269202tr_TR
dc.date.accessioned2021-10-27T11:00:08Z
dc.date.available2021-10-27T11:00:08Z
dc.date.issued2011-10
dc.description.abstractAnti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC50 values were 0.09 mu M for MDA-MB-231 and 3.05 mu M for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment.en_US
dc.identifier.citationUlukaya, E. vd. (2011). “Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo”. European Journal of Medicinal Chemistry, 46(10), 4957-4963.en_US
dc.identifier.endpage4963tr_TR
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue10tr_TR
dc.identifier.pubmed21885165tr_TR
dc.identifier.scopus2-s2.0-80053177765tr_TR
dc.identifier.startpage4957tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2011.07.055
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S022352341100568X
dc.identifier.urihttp://hdl.handle.net/11452/22503
dc.identifier.volume46tr_TR
dc.identifier.wos000296041600018tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalEuropean Journal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectPalladium(II) complexen_US
dc.subjectBreast canceren_US
dc.subjectCytotoxicityen_US
dc.subjectApoptosisen_US
dc.subjectTreatmenten_US
dc.subjectPlatinum(ıı) complexesen_US
dc.subjectBiological evaluationen_US
dc.subjectCytotoxic activityen_US
dc.subjectPd(ıı)en_US
dc.subjectPt(ıı)en_US
dc.subjectAssayen_US
dc.subjectMtten_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeDeath receptor 4en_US
dc.subject.emtreeDeath receptor 5en_US
dc.subject.emtreeMatrigelen_US
dc.subject.emtreePaclitaxelen_US
dc.subject.emtreePalladium complexen_US
dc.subject.emtreePyridine derivativeen_US
dc.subject.emtreeSaccharin sodiumen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAntineoplastic activityen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeCancer cell cultureen_US
dc.subject.emtreeCancer inhibitionen_US
dc.subject.emtreeCancer invasionen_US
dc.subject.emtreeCancer therapyen_US
dc.subject.emtreeCell deathen_US
dc.subject.emtreeCell strain mcf 7en_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeDrug synthesisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIc 50en_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeIn vivo studyen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreeNonhumanen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshCell line, tumoren_US
dc.subject.meshCoordination complexesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, inbred BALB Cen_US
dc.subject.meshPalladiumen_US
dc.subject.scopusBenzisothiazole; Palladium; 2-Phenylpyridineen_US
dc.subject.wosChemistry, medicinalen_US
dc.titleAnti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivoen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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