Hepatocellular carcinoma in children and effect of living-donor liver transplantation on outcome

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dc.contributor.authorArıkan, Çiğdem
dc.contributor.authorKılıç, Murat
dc.contributor.authorNart, Deniz
dc.contributor.authorÖzgenç, Funda
dc.contributor.authorTokat, Yaman
dc.contributor.authorYağcı, Raşit V.
dc.contributor.authorAydoğdu, Sema
dc.contributor.buuauthorÖzkan, Tuğba
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatrik Gastroenteroloji, Hepatoloji ve Beslenme Anabilim Dalı.tr_TR
dc.contributor.scopusid7004474005tr_TR
dc.date.accessioned2021-09-10T11:24:06Z
dc.date.available2021-09-10T11:24:06Z
dc.date.issued2006
dc.description.abstractHepatocellular carcinoma (HCC) is primarily observed in the older children and in most cases it develops in association with liver cirrhosis. Liver transplantation offers a good chance for long-term cure. To evaluate the outcome of children with HCC and the impact of living-donor orthotopic liver transplantation (OLT) on survival a retrospective review of radiographic, laboratory, pathologic, and therapeutic data in 13 children (six female and seven male) with chronic liver disease accompanied with HCC were studied. The patients were divided into two groups according to therapeutic modality: transplanted and non-transplanted patients. Kaplan-Meier survival curves in various therapeutic groups were plotted. The mean age of patients was 6.4 +/- 4.8 yr. Pediatric end-stage liver disease score was adapted to model for end-stage liver disease score for HCC and ranged between 1-44 and 18-44, respectively. The underlying liver diseases were tyrosinemia type 1 (n = 6), chronic hepatitis B infection (n equals;6), glycogen storage disease type 1 (n = 1). Alfa-feto protein levels were elevated in all patients except one. Median number of tumor nodules was three (1-10), median maximal diameter of tumor nodules was 3.4 cm (0.5-8). Eleven patients were eligible for OLT whereas two patients were not eligible. Seven of the 11 patients considered for transplantation underwent living-donor OLT. Remaining four patients died while waiting on cadaveric transplant list. Overall 1 and 4-yr survival rates for all patients were 53.3 and 26.6%, respectively, and were found significantly higher in transplanted children than non-transplanted children (72%, 72% vs. 33% and 16.6%). No patient had tumor recurrence at median of 36-month follow-up after OLT. OLT is a life-saving procedure for children with chronic liver disease accompanying with HCC. Living-donor OLT avoids the risk of tumor progression and transplant ineligibility in these children.en_US
dc.identifier.citationArıkan, C. vd. (2006). ''Hepatocellular carcinoma in children and effect of living-donor liver transplantation on outcome''. Pediatric Transplantation, 10(1), 42-47.en_US
dc.identifier.endpage47tr_TR
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue1tr_TR
dc.identifier.pubmed16499586tr_TR
dc.identifier.scopus2-s2.0-33645989454tr_TR
dc.identifier.startpage42tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1399-3046.2005.00395.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1399-3046.2005.00395.x
dc.identifier.urihttp://hdl.handle.net/11452/21855
dc.identifier.volume10tr_TR
dc.identifier.wos000235371400008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPediatricsen_US
dc.subjectTransplantationen_US
dc.subjectSurvivalen_US
dc.subjectPediatric liver transplantationen_US
dc.subjectPediatric end-stage liver disease scoreen_US
dc.subjectModel for end-stage liver disease score for hepatocellular carcinomaen_US
dc.subjectChronic liver diseaseen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectTumorsen_US
dc.subjectCriteriaen_US
dc.subjectSurvivalen_US
dc.subjectCirrhosisen_US
dc.subjectInfectionen_US
dc.subjectHepatoblastomaen_US
dc.subjectChildhooden_US
dc.subjectNatural-historyen_US
dc.subject.scopusHepatoblastoma; Liver Neoplasms; Metastasectomyen_US
dc.subject.wosPediatricsen_US
dc.subject.wosTransplantationen_US
dc.titleHepatocellular carcinoma in children and effect of living-donor liver transplantation on outcomeen_US
dc.typeArticle
dc.wos.quartileQ3 (Transplantation)en_US
dc.wos.quartileQ2 (Pediatrics)en_US

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