Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia

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dc.contributor.authorUlus, İsmail Hakkı
dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorEralp, Oya
dc.contributor.buuauthorKocatürk, Meriç
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Bilimler Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-4242-8609tr_TR
dc.contributor.orcid0000-0001-9836-0749tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.researcheridAAG-2943-2020tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid35944810500tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid24472964600tr_TR
dc.contributor.scopusid36437200800tr_TR
dc.date.accessioned2021-12-30T11:44:20Z
dc.date.available2021-12-30T11:44:20Z
dc.date.issued2010-06
dc.description.abstractSepsis/endotoxemia causes platelet dysfunctions, abnormalities in coagulation and hemostatic mechanisms leading to organ dysfunctions and mortality. Choline prevents organ injury and improves survival during endotoxemia. The main objective of the present study was to determine the effects of choline or cytidine-5'-diphosphocholine (CDP-choline) on endotoxin-induced activation of coagulation and development of disseminated intravascular coagulation (DIC). Dogs were treated intravenously (i.v.) with saline, choline (20 mg/kg), or CDP-choline (70 mg/kg) three times with 4-h intervals starting 5 min before i.v. injection of endotoxin (1 mg/kg). Platelet counts and functions, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, coagulation factors, D-dimer and antithrombin (AT) were measured before and at 0.5-96 h after endotoxin. Circulating platelet, fibrinogen, coagulation factors and AT were decreased, whereas PT and aPTT were prolonged and serum D-dimer levels were elevated after endotoxin. Endotoxin-induced reductions in platelet counts and functions, fibrinogen, coagulation factors and AT were attenuated or blocked by choline or CDP-choline. Choline or CDP-choline blocked endotoxin-induced prolongation in PT and aPTT and enhancement in D-dimer. Elevated DIC scores were attenuated by choline and blocked by CDP-choline. Choline administration increased serum choline concentrations and caused bradycardia. Choline also increased choline and acetylcholine contents of circulating mononuclear cells and inhibited radioligand binding to their cholinergic receptors. These data show that choline administration, as choline chloride or CDP-choline, restores the abnormalities in the primary, secondary, and tertiary hemostasis and prevents the development of DIC during experimental endotoxemia in dogs probably by increasing both neuronal and nonneuronal cholinergic activity. Blood Coagul Fibrinolysis 21:339-348en_US
dc.description.sponsorshipTürkiye Bilimler Akademisi (TÜBA)tr_TR
dc.identifier.citationYılmaz, Z. vd. (2010). "Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia". Blood Coagulation and Fibrinolysis, 21(4), 339-348.en_US
dc.identifier.endpage348tr_TR
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue4tr_TR
dc.identifier.pubmed20410813tr_TR
dc.identifier.scopus2-s2.0-77951911170tr_TR
dc.identifier.startpage339tr_TR
dc.identifier.urihttps://doi.org/10.1097/MBC.0b013e328338ce31
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20410813/
dc.identifier.urihttp://hdl.handle.net/11452/23767
dc.identifier.volume21tr_TR
dc.identifier.wos000277925800008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.bapV-2003/86tr_TR
dc.relation.bapT-2003/50tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalBlood Coagulation and Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCDP-cholineen_US
dc.subjectCholineen_US
dc.subjectDICen_US
dc.subjectDogen_US
dc.subjectEndotoxinen_US
dc.subjectHemostasisen_US
dc.subjectIncreases serum-insulinen_US
dc.subjectInflammatory responseen_US
dc.subjectSevere sepsisen_US
dc.subjectAcetylcholineen_US
dc.subjectStimulationen_US
dc.subjectReleaseen_US
dc.subjectSystemen_US
dc.subjectInvolvementen_US
dc.subjectMetabolitesen_US
dc.subjectDysfunctionen_US
dc.subjectHematologyen_US
dc.subject.emtreeAntithrombinen_US
dc.subject.emtreeBlood clotting factoren_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeD dimeren_US
dc.subject.emtreeEndotoxinen_US
dc.subject.emtreeFibrinogenen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCholinergic activityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisseminated intravascular clottingen_US
dc.subject.emtreeDogen_US
dc.subject.emtreeEndotoxemiaen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHemostasisen_US
dc.subject.emtreeHigh performance liquid chromatographyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePartial thromboplastin timeen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProthrombin timeen_US
dc.subject.emtreeThrombocyte counten_US
dc.subject.emtreeThrombocyte functionen_US
dc.subject.emtreeThrombocytopeniaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood coagulationen_US
dc.subject.meshCholineen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshDisseminated intravascular coagulationen_US
dc.subject.meshDogsen_US
dc.subject.meshEndotoxemiaen_US
dc.subject.meshEndotoxinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.wosHematologyen_US
dc.titleCholine or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemiaen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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