Factors influencing axillary node metastasis in breast cancer

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dc.contributor.buuauthorÇetintaş, Sibel Kahraman
dc.contributor.buuauthorKurt, Meral
dc.contributor.buuauthorÖzkan, Lütfi
dc.contributor.buuauthorEngin, Kayıhan
dc.contributor.buuauthorGökgöz, Şehsuvar
dc.contributor.buuauthorTaşdelen, İsmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-1637-910Xtr_TR
dc.contributor.researcheridAAA-7047-2020tr_TR
dc.contributor.researcheridAAA-3961-2020tr_TR
dc.date.accessioned2021-10-19T11:28:50Z
dc.date.available2021-10-19T11:28:50Z
dc.date.issued2006
dc.description.abstractAims and background: The status of the axillary lymph nodes at the time of diagnosis has been accepted as one of the most important prognostic factors for the overall and disease-free survival of patients with breast cancer. The aim of our study was to determine which factors influence axillary node involvement in invasive breast cancer. Methods: The data presented here were obtained from 344 patients who were treated for invasive breast cancer at the Department of Radiation Oncology, Uluda6 University Medical College, Bursa, Turkey. Possible prognostic factors were categorized as patient related and tumor related. The Mann-Whitney U test was used for univariate analysis and logistic regression was used for multivariate analysis. Results: In univariate analysis, a familial cancer history (P 0.0042), age < 40 years (P = 0.0276), higher T stage (P < 0.0000), nipple involvement (P = 0.0345), skin involvement (P = 0.0270), perineural invasion (P = 0.0231), and lymphatic vessel invasion (P < 0.0000) were correlated with increased axillary node involvement. A higher incidence of >= 4 involved lymph nodes was associated with higher T stage (P = 0.0004), nipple involvement (P = 0.0292), presence of an extensive intraductal component (P = 0.0023)i skin involvement (P = 0.0008), perineural invasion (P = 0.0523), and lymphatic vessel invasion (P < 0.0000) in univariate analysis. In multivariate analysis, age < 40 years (P = 0.0454), cancer history within the family (P = 0.0024), higher T stage (P = 0.0339), lymphatic vessel invasion (P = 0.0003), and perineural invasion (P = 0.0408) were found to be independent factors for axillary lymph node positivity. Age < 40 years (P = 0.0221), perineural invasion (P = 0.0408), and an extensive intraductal component (P = 0.0132) were associated with an increased incidence of 4 involved nodes in the logistic regression analysis. In patients with breast cancer, the incidence of axillary lymph node involvement was independently influenced by age < 40 years, presence of cancer history within the family, higher T stage, lymphatic vessel invasion, and perineural invasion. Conclusions: In conclusion, absence of familial cancer history, presence of lymphatic vessel invasion, higher T stage, and age below 40 years independently increased the risk of axillary node involvement. Presence of perineural invasion and lymphatic vessel invasion, age below 40, and an extensive intraductal component of more than 25% independently affected the risk of having A nodes involved. Patients characterized by these factors may be classified into a higher risk group for nodal involvement, but more data are needed to define factors that can help in the decision-making regarding the omission of axillary treatment.en_US
dc.identifier.citationÇetintaş, S. K. vd. (2006). ''Factors influencing axillary node metastasis in breast cancer''. Tumori Journal, 92(5), 416-422.en_US
dc.identifier.endpage422tr_TR
dc.identifier.issn0300-8916
dc.identifier.issn2038-2529
dc.identifier.issue5tr_TR
dc.identifier.pubmed17168435tr_TR
dc.identifier.scopus2-s2.0-33845267263tr_TR
dc.identifier.startpage416tr_TR
dc.identifier.urihttps://doi.org/10.1177/030089160609200509
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/030089160609200509
dc.identifier.urihttp://hdl.handle.net/11452/22411
dc.identifier.volume92tr_TR
dc.identifier.wos000242313900009tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.journalTumori Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectPrognostic factorsen_US
dc.subjectBreast canceren_US
dc.subjectAxillary lymph node involvementen_US
dc.subjectInvolvementen_US
dc.subjectRecurrenceen_US
dc.subjectDissectionen_US
dc.subjectTumor sizeen_US
dc.subjectVessel invasionen_US
dc.subjectPrognostic-significanceen_US
dc.subjectConservative managementen_US
dc.subjectPostmastectomy radiotherapyen_US
dc.subjectClinical-practice guidelinesen_US
dc.subjectSentinel lymph-nodeen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSkin canceren_US
dc.subject.emtreeRisk assessmenten_US
dc.subject.emtreeRank sum testen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeNippleen_US
dc.subject.emtreeMedical decision makingen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeLymphangiomaen_US
dc.subject.emtreeLymph node metastasisen_US
dc.subject.emtreeLogistic regression analysisen_US
dc.subject.emtreeIntraductal carcinomaen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHigh risk populationen_US
dc.subject.emtreeDisease free survivalen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCancer stagingen_US
dc.subject.emtreeCancer invasionen_US
dc.subject.emtreeCancer incidenceen_US
dc.subject.emtreeCancer diagnosisen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeAxillary lymph nodeen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAdulten_US
dc.subject.scopusSentinel Lymph Node Biopsy; Lymphoscintigraphy; Micrometastasisen_US
dc.subject.wosOncologyen_US
dc.titleFactors influencing axillary node metastasis in breast canceren_US
dc.typeArticle

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