Comparative study of tissue oxidative stress in hydrocotyl bonarienssis treated rats fed with dietary galactose

Basit Görünüm
dc.contributor.authorOladipo, Ajani Emmanuel
dc.contributor.authorOlugbenga, Adebawo
dc.contributor.authorAdewale, Salau Bamidele
dc.contributor.authorOlalekan, Osineye Paul
dc.contributor.authorMoronke, Adeyanju Muinat
dc.contributor.authorKayode, Aro Olusegun
dc.date.accessioned2021-03-08T06:40:13Z
dc.date.available2021-03-08T06:40:13Z
dc.date.issued2008
dc.description.abstractStudies on toxicity of galactose and its management have been largely concentrated on the lens. The present study compare the oxidative stress that occurred in various tissues of rats placed on dietary galactose and simultaneously administered with different doses of Hydrocotyl bonariensis leave extract. Male rats weanling rats placed on dietary galactose and administered (orally) with different doses of the extract were used in the study. After four (4) weeks of treatment a significant increased level of lens and liver peroxidation with reduced activity of catalase, superoxide dismutase and reduced glutathione (GSH) level was observed in rats placed on dietary galactose, whereas the kidney was not significantly affected (though superoxide dismutase activity of the kidney increases). Administration of 500mgKg-1 of the extract lowered the level of peroxidation of these tissues and significantly increased the catalase activity and GSH level, while superoxide dismutase activity only increased in the lens and the kidney. Though treatment with 1000mgKg-1 of the extract reduced the level of peroxidation of these tissues, it does not increase the antioxidant status. Our findings suggests that, the lens and liver is the most at risk of oxidative stress generated with dietary galactose but not the kidney and that Hydrocotyl bonariensis leave possess active components that may be beneficial in reducing the effect of these oxidative stress when administered at lower dose.en_US
dc.identifier.citationOladipo, A. E. vd. (2008). "Comparative study of tissue oxidative stress in hydrocotyl bonarienssis treated rats fed with dietary galactose ". Journal of Biological and Environmental Sciences, 2(4), 15-21.tr_TR
dc.identifier.endpage21tr_TR
dc.identifier.issn1307-9530
dc.identifier.issn1308-2019
dc.identifier.issue4tr_TR
dc.identifier.startpage15tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/497829
dc.identifier.urihttp://hdl.handle.net/11452/17199
dc.identifier.volume2tr_TR
dc.language.isoenen_US
dc.publisherUludağ Üniversitesitr_TR
dc.relation.journalJournal of Biological and Environmental Sciencestr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTissuesen_US
dc.subjectOxidantsen_US
dc.subjectPeroxidationen_US
dc.subjectAntioxidantsen_US
dc.subjectGalactoseen_US
dc.subjectHydrocotyl bonariensisen_US
dc.titleComparative study of tissue oxidative stress in hydrocotyl bonarienssis treated rats fed with dietary galactoseen_US
dc.typeArticleen_US

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