Doğal enfekte köpeklerde dirofilaria immitis mikrofilerlerine ivermektinin etkisi
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Date
1992
Authors
Demir, Cem
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Modifiye Knott yöntemi ile yapılan muayene sonucu Gemlik Aske ri Veteriner Araştımıa Enstitüsü ve Egitim Merkezi Komutanlığı'nda yetiştirilen 168 köpekten 5'i (% 2.98) Dirofilaria immilis ile enfekte bulun muştur. Bu köpeklere ivemıektinin 200 mcg/kg dozu, derialtı yolla peşpeşe 2 gün uygulanmış ve sağaltını sonrası kandaki mikrojiler sayısın da meydana gelen degişmeler incelenmiştir. İvemıektin tedavisinden sonraki 7'nci giinden 90'ıncı güne kadar mikroji/er sayısında sağaltını öncesine göre ortalama olarak % 99. 77'den % 99.22'ye kadar degişen azalma olmuştur. Daha sonraki günlerde mikroji/er sayısında Jasmi bir mtış dikkati çekmiş ve bu oran 120'nci 'günde % 97.79, 150'nci günde % 95.03, 180'inci günde % 94.50, 210'uncu günde % 94.04 olarak saptanmıştır. 210'uncu günde tek doz olarak uygulanan aym miktar ivennektin mikroftler sayısmdaki azalmayı % 99.96'ya yükseltiştir. Araştırna sonunda ivemıektinin yüksek bir mikrofilarisid etkisi olduğu ve uygulanan dozda köpeklerde herhangi bir olumsuz etki göstermediği saptanmıştır.
Five of 168 dogs bred at the Anny Veterinary Research and Training Center at Gemlik, Bursa were found to be infected with Dirofian immilis (2.98 percent) by using Modified Knott method. The changes in the counts of microfilariae were studied after Ivem ectin therapy (200 mcglkg body wt. injected daily sc., in two consecutive days). Ivennectin decreased the cowıts down by 99.77 and 99.22 percent at average by comparing witlı the cowıts taken before treatments. Following these reductions, a temporary increase was observed and the efftcacy rates were 97.79, 95.03, 94.50 and 94.04 percent by 120 th, 150 th, 180 th and 210 tlı days respectively. And a final application of the drug at the same dose and route resulted in 99.96 % reduction of microfilarial counts. With these results Ivemıectin was considered aslıglıly effective microfilaricid chemotlıerapeutic drug for the treatment of Dirofilariosis in dogs. And exlıibited no side effects at tlıe dosage and route of administration used here.
Five of 168 dogs bred at the Anny Veterinary Research and Training Center at Gemlik, Bursa were found to be infected with Dirofian immilis (2.98 percent) by using Modified Knott method. The changes in the counts of microfilariae were studied after Ivem ectin therapy (200 mcglkg body wt. injected daily sc., in two consecutive days). Ivennectin decreased the cowıts down by 99.77 and 99.22 percent at average by comparing witlı the cowıts taken before treatments. Following these reductions, a temporary increase was observed and the efftcacy rates were 97.79, 95.03, 94.50 and 94.04 percent by 120 th, 150 th, 180 th and 210 tlı days respectively. And a final application of the drug at the same dose and route resulted in 99.96 % reduction of microfilarial counts. With these results Ivemıectin was considered aslıglıly effective microfilaricid chemotlıerapeutic drug for the treatment of Dirofilariosis in dogs. And exlıibited no side effects at tlıe dosage and route of administration used here.
Description
Keywords
Köpek, Dirofilaria immitis, Dog, Microfilaricid, Mikrofiler, İvemiektin, Tedavi, Microfilarisid, Ivennectin, Antihelminthic chemo therapy
Citation
Coşkun, Ş. Z. vd. (1992). "Doğal enfekte köpeklerde dirofilaria immitis mikrofilerlerine ivermektinin etkisi" Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 11(2),121-128.