The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome

Simple item page
dc.contributor.authorSelimoğlu, Hadi
dc.contributor.authorDuran, Cevdet
dc.contributor.buuauthorKıyıcı, Sinem
dc.contributor.buuauthorErsoy, Canan
dc.contributor.buuauthorGüçlü, Metin
dc.contributor.buuauthorÖzkaya, Güven
dc.contributor.buuauthorTuncel, Ercan
dc.contributor.buuauthorErtürk, Erdinç
dc.contributor.buuauthorİmamoğlu, Şazi
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0297-846Xtr_TR
dc.contributor.researcheridAAJ-6536-2021tr_TR
dc.contributor.researcheridABI-4847-2020tr_TR
dc.contributor.researcheridA-4421-2016tr_TR
dc.contributor.researcheridAAH-8861-2021tr_TR
dc.contributor.scopusid12753880400tr_TR
dc.contributor.scopusid6701485882tr_TR
dc.contributor.scopusid15073842600tr_TR
dc.contributor.scopusid16316866500tr_TR
dc.contributor.scopusid7006929833tr_TR
dc.contributor.scopusid7005488796tr_TR
dc.contributor.scopusid6602297533tr_TR
dc.date.accessioned2021-10-21T11:06:06Z
dc.date.available2021-10-21T11:06:06Z
dc.date.issued2010-04
dc.description.abstractInsulin resistance (IR) is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of IR and glucose metabolism. Aim of this study was aimed to determine the effect of vitamin D replacement therapy on glucose metabolism, insulin, and androgen levels in obese, insulin-resistant women with PCOS. Eleven women with PCOS were included in the study. Mean age of the patients was 23.6+/-5.7 yr, body mass index 33.9+/-5.1 kg/m(2). Six patients (54.5%) had acantosis nigricans and 10 (90.9%) oligoamenorrhea. The mean Ferriman Gallwey score was 14.1+/-4.6. Only 2 women were within the normal limits of vitamin D levels as >20 ng/ml. Three weeks after the administration of the single dose of 300,000 units of vitamin D3 orally, 25-hydroxyvitamin D3 significantly increased from 16.9+/-16 ng/ml to 37.1+/-14.6 ng/ml (p: 0.027) and only 2 women were detected to have vitamin D3 levels <20 ng/ml. Although glucose and insulin levels were decreased non-significantly, homeostasis model assesment (HOMA)-IR significantly decreased from 4.41+/-1.38 to 3.67+/-1.48 (p: 0.043). No significant alterations were witnessed at the levels of DHEAS, total and free testosterone, androstenedione. No correlation was found between vitamin D with HOMA and other hormonal parameters. In conclusion, women with PCOS have mostly insufficient vitamin D levels, and vitamin D replacement therapy may have a benefical effect on IR in obese women with PCOS.en_US
dc.identifier.citationSelimoğlu, H. vd. (2010). "The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome". Journal of Endocrinological Investigation, 33(4), 234-238.en_US
dc.identifier.endpage238tr_TR
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue4tr_TR
dc.identifier.pubmed19820295tr_TR
dc.identifier.scopus2-s2.0-77953562058tr_TR
dc.identifier.startpage234tr_TR
dc.identifier.urihttps://doi.org/10.1007/BF03345785
dc.identifier.urihttps://link.springer.com/article/10.1007/BF03345785
dc.identifier.urihttps://doi.org/10.1007/10.3275/6560
dc.identifier.urihttp://hdl.handle.net/11452/22427
dc.identifier.volume33tr_TR
dc.identifier.wos000278570700006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInsulin resistanceen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectVitamin Den_US
dc.subjectGlucose metabolismen_US
dc.subjectAndrogenen_US
dc.subjectLong-term treatmenten_US
dc.subjectGlucose-toleranceen_US
dc.subjectHypovitaminosis-Den_US
dc.subjectObese womenen_US
dc.subjectSensitivityen_US
dc.subjectSecretionen_US
dc.subject1,25-dihydroxyvitamin-D3en_US
dc.subjectPrevalenceen_US
dc.subjectReceptoren_US
dc.subjectTestosteroneen_US
dc.subjectEndocrinology & metabolismen_US
dc.subject.emtreeAndrogenen_US
dc.subject.emtreeAndrostenedioneen_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeInsulinen_US
dc.subject.emtreePrasteroneen_US
dc.subject.emtreeTestosteroneen_US
dc.subject.emtreevitamin Den_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeVitaminen_US
dc.subject.emtreeAcanthosis nigricansen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGlucose metabolismen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInsulin resistanceen_US
dc.subject.emtreeObesityen_US
dc.subject.emtreeOligomenorrheaen_US
dc.subject.emtreeOvary polycystic diseaseen_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSubstitution therapyen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeInsulin resistanceen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreePolycystic ovary syndromeen_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAndrogensen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood glucoseen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulinen_US
dc.subject.meshInsulin resistanceen_US
dc.subject.meshObesityen_US
dc.subject.meshPolycystic ovary syndromeen_US
dc.subject.meshVitamin Den_US
dc.subject.meshVitaminsen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusOvary Polycystic Disease; Ergocalciferols; Calcitriol Receptorsen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.titleThe effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndromeen_US
dc.typeArticle
dc.wos.quartileQ4en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus