Effect of central and peripheral ınjected nesfatin-1 on electrocardiography in rats

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dc.contributor.buuauthorÇiftçe, Kübra
dc.contributor.buuauthorGüvenç, Gökçen
dc.contributor.buuauthorBas, Ayşenur
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.contributor.orcid0000-0002-2647-0946tr_TR
dc.contributor.orcid0000-0002-1413-3651tr_TR
dc.contributor.orcid0000-0002-7825-4823tr_TR
dc.contributor.orcid0000-0002-6605-3514tr_TR
dc.date.accessioned2020-12-21T11:53:23Z
dc.date.available2020-12-21T11:53:23Z
dc.date.issued2019-04-14
dc.description.abstractNesfatin-1 is an anorexic nucleobindin-2 -derived peptide and it has directly and centrally effect on the heart. The current study was designed to determine the effect of centrally and peripherally administered nesfatin-1 on electrocardiography (ECG) of healthy both fasted rats for 12 h and satiated rats fed ad libitum. In order to record ECG, the electrodes were placed limbs of at lead II under ketamine (50 mg/kg; im) and xylazine (20 mg/kg; im) anesthesia mix. Centrally administered different doses of nesfatin-1 (100 and 200 pmol; icv) resulted in dose- and time-dependently a statistically significant increase (p <0.05) in T wave, Q-T interval, and R-R interval duration without changing in ECG waves’ amplitude in both satiated and fasted rats. In a similar way, peripheral administration of nesfatin-1 (80 μg/kg; iv) in satiated rats prolonged statistically significant (p <0.05) T wave, Q-T interval, and R-R interval without producing a change in ECG waves’ amplitude. Moreover, icv administered nesfatin-1 in fasted and satiated rats, and iv injected nesfatin-1 in satiated rats induced a statistically significant decrease in heart rate (p <0.05). In conclusion, our findings suggest that centrally and peripherally administrated nesfatin-1 caused a delay in T wave, Q-T interval and two R-waves interval duration in ECG so that leading to a bradycardic effect in heart rate.en_US
dc.identifier.citationÇiftçi, K. vd. (2019). "Effect of central and peripheral ınjected nesfatin-1 on electrocardiography in rats". Uludağ Üniversitesi Veteriner Fakültesi, 38(1), 10-17tr_TR
dc.identifier.endpage17tr_TR
dc.identifier.issn1301-3173
dc.identifier.issue1tr_TR
dc.identifier.startpage10tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/763103
dc.identifier.urihttp://hdl.handle.net/11452/14506
dc.identifier.volume38tr_TR
dc.language.isoenen_US
dc.publisherBursa Uludağ Üniversitesitr_TR
dc.relation.journalVeteriner Hekimlikte Araştırma Dergisi / Journal of Research in Veterinary Medicinetr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNesfatin-1en_US
dc.subjectElectrocardiographyen_US
dc.subjectIntracerebroventricularen_US
dc.subjectIntravenousen_US
dc.subjectHeart rateen_US
dc.titleEffect of central and peripheral ınjected nesfatin-1 on electrocardiography in ratsen_US
dc.typeArticleen_US

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2019 Cilt 38 Sayı 1