Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis

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dc.contributor.authorGuzman, Josune
dc.contributor.authorCostabel, Ulrich
dc.contributor.buuauthorUzaslan, Esra Kunt
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.scopusid8761653500tr_TR
dc.date.accessioned2021-09-22T13:11:51Z
dc.date.available2021-09-22T13:11:51Z
dc.date.issued2005
dc.description.abstractBackground and Objectives: In immunocytochemical preparations of bronchoalveolar lavage (BAL) cells from patients with extrinsic allergic alveolitis (EAA), we observed the presence of alveolar macrophages with cockade-like structures in their cytoplasm ( cockade+ alveolar macrophages). These cockade+ alveolar macrophages may reflect a subpopulation of alveolar macrophages which may show a different predominance in various interstitial lung diseases. In this study we aimed to compare the frequency of cockade+ alveolar macrophages in patients with EAA ( n = 14) with the results obtained in patients with sarcoidosis ( n = 11), idiopathic interstitial pneumonia ( IIP; n = 10) and control subjects ( n = 8). We also investigated the expression of the transferrin receptor CD71 on cockade+ alveolar macrophages. Methods: In BAL fluid, the total number of cells and differential counts were determined, and immunocytologic examinations of macrophages and lymphocytes were done using monoclonal antibodies. The percentage of cockade+ alveolar macrophages was determined by counting 300 macrophages in the CD20 field of an immunocytochemical slide. Results: The percentage of cockade+ alveolar macrophages was significantly higher in the EAA group ( 36 +/- 9%) compared to patients with sarcoidosis ( 12 +/- 5%) or IIP ( 11 +/- 10%) and control subjects ( 3 +/- 1%; p < 0.001). The proportion of CD71+ alveolar macrophages was significantly lower in EAA than in the other groups ( p < 0.01), and the CD71 antigen was expressed on a significantly lower proportion of cockade+ alveolar macrophages compared to cockade - alveolar macrophages in EAA ( p < 0.001). Conclusion: We conclude that cockade+ alveolar macrophages could play a role in the pathogenesis and differential diagnosis EAA.en_US
dc.identifier.citationUzaslan, E. vd. (2005). "Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis". Respiration, 72(1), 46-51.en_US
dc.identifier.endpage51tr_TR
dc.identifier.issn0025-7931
dc.identifier.issn1423-0356
dc.identifier.issue1tr_TR
dc.identifier.pubmed15753634tr_TR
dc.identifier.scopus2-s2.0-16344394867tr_TR
dc.identifier.startpage46tr_TR
dc.identifier.urihttps://doi.org/10.1159/000083400
dc.identifier.urihttps://www.karger.com/Article/Abstract/83400
dc.identifier.urihttp://hdl.handle.net/11452/22065
dc.identifier.volume72tr_TR
dc.identifier.wos000227488400009tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalRespirationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRespiratory systemen_US
dc.subjectAlveolar macrophagesen_US
dc.subjectExtrinsic allergic alveolitisen_US
dc.subjectTransferrin receptoren_US
dc.subjectInterstitial lung-diseasesen_US
dc.subjectBronchoalveolar lavage fluiden_US
dc.subjectHypersensitivity pneumonitisen_US
dc.subjectLymphocytic alveolitisen_US
dc.subjectPulmonary sarcoidosisen_US
dc.subjectTransferrin receptorsen_US
dc.subjectPeripheral-blooden_US
dc.subjectSurface-antigensen_US
dc.subjectT-cellsen_US
dc.subjectExpressionen_US
dc.subject.emtreeCD71 antigenen_US
dc.subject.emtreeMonoclonal antibodyen_US
dc.subject.emtreeTransferrin receptoren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAllergic pneumonitisen_US
dc.subject.emtreeAntigen expressionen_US
dc.subject.emtreeCell counten_US
dc.subject.emtreeCell ultrastructureen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeImmunocytochemistryen_US
dc.subject.emtreeInterstitial pneumoniaen_US
dc.subject.emtreeLung alveolus macrophageen_US
dc.subject.emtreeLung lavageen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSarcoidosisen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAlveolitis, extrinsic allergicen_US
dc.subject.meshAntibodies, monoclonalen_US
dc.subject.meshBiological markersen_US
dc.subject.meshBronchoalveolar lavageen_US
dc.subject.meshBronchoalveolar lavage fluiden_US
dc.subject.meshCell adhesion moleculesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHla-dq antigensen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulinsen_US
dc.subject.meshInclusion bodiesen_US
dc.subject.meshMacrophages, alveolaren_US
dc.subject.meshMaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshReceptors, immunologicen_US
dc.subject.meshReceptors, transferrinen_US
dc.subject.meshT-lymphocytesen_US
dc.subject.scopusAllergic Pneumonitis; Precipitins; Saccharopolyspora Rectivirgulaen_US
dc.subject.wosRespiratory systemen_US
dc.titleCockade-like structures in alveolar macrophages in extrinsic allergic alveolitisen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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