Disturbed dental development of permanent teeth in children with solid tumors and lymphomas

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dc.contributor.buuauthorÇubukçu, Çiğdem Elbek
dc.contributor.buuauthorSevinir, Betül
dc.contributor.buuauthorErcan, İlker
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Diş Bakım Ünitesi.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatrik Onkoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1480-2907tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.researcheridAAH-2726-2021tr_TR
dc.contributor.researcheridAAH-1570-2021tr_TR
dc.contributor.scopusid15062319400tr_TR
dc.contributor.scopusid6603199915tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.date.accessioned2021-11-23T11:17:43Z
dc.date.available2021-11-23T11:17:43Z
dc.date.issued2012-01
dc.description.abstractBackground. Deficient dental root development has been reported after conventional pediatric anticancer therapy but less information is available on children with solid tumors and lymphomas. Procedure. We examined dental development from panoramic radiographs (PRGs) of 37 childhood cancer survivors (CCS) treated under the age of 10 years with multimodal chemotherapy (CT) and/or head and neck radiotherapy (RT). A novel defect index (DeI) was used to describe the total damage to permanent dentition. The DeI was also tested in matched controls. Results. All CCS had dental disturbances including abnormal root development (86.4%), microdontia (13.5%) and tooth agenesis (16.2%). Testing the controls gave the mean DeI value 1.9 +/- 2.7(range, 0-12), while the index scores in the study group varied from 0 to 49 (mean 10.8 +/- 11.2) (P < 0.01). The statistical differences in the mean DeI values were insignificant between CT and CT and RT groups (P > 0.05). Conclusions. Children treated for solid tumors and lymphomas are at considerable risk of some disturbances in developing dental structures. RT increased the severity of disturbances induced by CT. Studies should further elucidate dose-, age and time-related effects of anticancer treatment on dental development.en_US
dc.identifier.citationÇubukçu, Ç. E. vd. (2012). "Disturbed dental development of permanent teeth in children with solid tumors and lymphomas". Pediatric Blood and Cancer, 58(1), 80-84.en_US
dc.identifier.endpage84tr_TR
dc.identifier.issn1545-5009
dc.identifier.issn1545-5017
dc.identifier.issue1tr_TR
dc.identifier.pubmed21254371tr_TR
dc.identifier.scopus2-s2.0-81155133247tr_TR
dc.identifier.startpage80tr_TR
dc.identifier.urihttps://doi.org/10.1002/pbc.22902
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/pbc.22902
dc.identifier.urihttp://hdl.handle.net/11452/22777
dc.identifier.volume58tr_TR
dc.identifier.wos000297641300016tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalPediatric Blood and Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectHematologyen_US
dc.subjectPediatricsen_US
dc.subjectAdverse effectsen_US
dc.subjectAnticancer treatmenten_US
dc.subjectChilden_US
dc.subjectPermanent dentitionen_US
dc.subjectChildhood-cancer survivorsen_US
dc.subjectStem-cell transplantationen_US
dc.subjectLong-term survivorsen_US
dc.subjectChemotherapyen_US
dc.subjectLeukemiaen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer combination chemotherapyen_US
dc.subject.emtreeCancer radiotherapyen_US
dc.subject.emtreeCancer survivoren_US
dc.subject.emtreeChilden_US
dc.subject.emtreeChildhood canceren_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDefect indexen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHypodontiaen_US
dc.subject.emtreeInfanten_US
dc.subject.emtreeLymphomaen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMicrodontiaen_US
dc.subject.emtreeNewbornen_US
dc.subject.emtreePanoramic radiographyen_US
dc.subject.emtreePreschool childen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRating scaleen_US
dc.subject.emtreeSchool childen_US
dc.subject.emtreeSolid tumoren_US
dc.subject.emtreeTooth developmenten_US
dc.subject.emtreeTooth malformationen_US
dc.subject.emtreeTooth rooten_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshDentition, permanenten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshLymphomaen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasmsen_US
dc.subject.meshOdontogenesisen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRadiography, panoramicen_US
dc.subject.meshToothen_US
dc.subject.meshTooth diseasesen_US
dc.subject.scopusTooth Abnormalities; Anodontia; Xerostomiaen_US
dc.subject.wosOncologyen_US
dc.subject.wosHematologyen_US
dc.subject.wosPediatricsen_US
dc.titleDisturbed dental development of permanent teeth in children with solid tumors and lymphomasen_US
dc.typeArticle
dc.wos.quartileQ3 (Hematology)en_US
dc.wos.quartileQ1 (Pediatrics)en_US

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