Vanadyl sulfate treatment improves oxidative stress and increases serum paraoxonase activity in streptozotocin-induced diabetic rats

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dc.contributor.buuauthorTaş, Sibel
dc.contributor.buuauthorSarandöl, Emre
dc.contributor.buuauthorZiyanok, Sedef Ayvalık
dc.contributor.buuauthorOcak, Nihal
dc.contributor.buuauthorSerdar, Zehra
dc.contributor.buuauthorDirican, Melahat
dc.contributor.departmentUludağ Üniversitesi/Fen Edebiyet Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.orcid0000-0002-0909-618Xtr_TR
dc.contributor.researcheridABE-6873-2020tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridAAG-6985-2021tr_TR
dc.contributor.researcheridAAH-6200-2021tr_TR
dc.contributor.scopusid7004343411tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.contributor.scopusid15128398000tr_TR
dc.contributor.scopusid23989248600tr_TR
dc.contributor.scopusid57222002284tr_TR
dc.contributor.scopusid6601919847tr_TR
dc.date.accessioned2021-10-14T10:52:58Z
dc.date.available2021-10-14T10:52:58Z
dc.date.issued2006
dc.description.abstractVanadyl sulfate (VS) may reduce oxidative stress related to its hypoglycemic and hypolipidemic effects in diabetes mellitus; besides, as a catalytic element, it may induce lipid peroxidation. Studies investigating effects of VS on the oxidative-antioxidative systems in diabetes yielded conflicting results, and this study was designed to investigate the effects of VS on the oxidative-antioxidative systems in streptozotocin-induced (65 mg/kg) diabetic rats. Vanadyl sulfate was administered in drinking water 0.75 mg/mL during 5 weeks after the induction of diabetes. Thirty-two male Wistar rats were randomly divided into four groups: control (C), control + vanadyl sulfate (C + VS), diabetes (D), and diabetes + vanadyl sulfate (D + VS). Vanadyl sulfate reduced the enhanced glucose, lipid, and tissue malondialdehyde levels and increased the reduced serum paraoxonase and arylesterase activity in the D + VS group. Plasma malondialdehyde level was significantly increased in the C + VS group, compared with the control group. Erythrocyte glutathione peroxidase activity was significantly higher in the C + VS and D + VS groups, compared with the C and the D groups, respectively.The results of the present study suggest that (i) VS has antioxidative potential in streptozotocin-treated rats, and it might be used as a supportive therapeutic agent in uncontrolled diabetes; (ii) VS treatment might play a role in the improvement of serum paraoxonase activity and, thus, inhibit the progression of atherosclerosis; (iii) the prooxidant potential of the VS should be taken into account.en_US
dc.identifier.citationTaş, S. vd. (2006). ''Vanadyl sulfate treatment improves oxidative stress and increases serum paraoxonase activity in streptozotocin-induced diabetic rats''. Nutrition Research, 26(12), 670-676.en_US
dc.identifier.endpage676tr_TR
dc.identifier.issn0271-5317
dc.identifier.issue12tr_TR
dc.identifier.scopus2-s2.0-33845283889tr_TR
dc.identifier.startpage670tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.nutres.2006.09.022
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0271531706002387
dc.identifier.urihttp://hdl.handle.net/11452/22343
dc.identifier.volume26tr_TR
dc.identifier.wos000243168400010tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.journalNutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNutrition & dieteticsen_US
dc.subjectVanadyl sulfateen_US
dc.subjectStreptozotocinen_US
dc.subjectParaoxonaseen_US
dc.subjectOxidative stressen_US
dc.subjectDiabetesen_US
dc.subjectAminoguanidineen_US
dc.subjectSusceptibilityen_US
dc.subjectLDLen_US
dc.subjectAntioxidant statusen_US
dc.subjectAutoxidative glycosylationen_US
dc.subjectGlucose autoxidationen_US
dc.subjectLipid-peroxidationen_US
dc.subjectIn-vivoen_US
dc.subjectPlasmaen_US
dc.subjectMellitusen_US
dc.subjectRattus norvegicusen_US
dc.subject.emtreeVanadyl sulfateen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeStreptozocinen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeLipiden_US
dc.subject.emtreeInsulinen_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeDrinking wateren_US
dc.subject.emtreeCarbohydrateen_US
dc.subject.emtreeAryldialkylphosphataseen_US
dc.subject.emtreeAlpha tocopherolen_US
dc.subject.emtreeVitamin blood levelen_US
dc.subject.emtreeTreatment outcomeen_US
dc.subject.emtreeTherapy effecten_US
dc.subject.emtreeStreptozocin diabetesen_US
dc.subject.emtreeSpecies comparisonen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeRandomizationen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeAntioxidant activityen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeLipid blood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCoronary artery atherosclerosisen_US
dc.subject.emtreeDiabetogenesisen_US
dc.subject.emtreeInsulin blood levelen_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeEnzyme blood levelen_US
dc.subject.emtreeDisease courseen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeDug inhibitionen_US
dc.subject.emtreeDrug effecten_US
dc.subject.scopusBis(Acetylacetonato)Oxovanadium(IV); Vanadium Compounds; Oxovanadium IVen_US
dc.subject.wosNutrition & Dieteticsen_US
dc.titleVanadyl sulfate treatment improves oxidative stress and increases serum paraoxonase activity in streptozotocin-induced diabetic ratsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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