Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors
dc.contributor.buuauthor | İlçöl, Yeşim Özarda | |
dc.contributor.buuauthor | Yılmaz, Zeki | |
dc.contributor.buuauthor | Cansev, Mehmet | |
dc.contributor.buuauthor | Ulus, İsmail Hakkı | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veterinerlik Fakültesi/İç Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-2918-5064 | tr_TR |
dc.contributor.orcid | 0000-0001-9836-0749 | tr_TR |
dc.contributor.researcherid | D-5340-2015 | tr_TR |
dc.contributor.researcherid | M-9071-2019 | tr_TR |
dc.contributor.researcherid | AAL-8873-2021 | tr_TR |
dc.contributor.scopusid | 35741320500 | tr_TR |
dc.contributor.scopusid | 35944810500 | tr_TR |
dc.contributor.scopusid | 8872816100 | tr_TR |
dc.contributor.scopusid | 7004271086 | tr_TR |
dc.date.accessioned | 2021-12-03T06:38:15Z | |
dc.date.available | 2021-12-03T06:38:15Z | |
dc.date.issued | 2009-09 | |
dc.description.abstract | We showed previously that choline administration protects dogs from endotoxin-induced multiple organ injury and platelet dysfunctions. Because sepsis/endotoxemia is associated with alterations in lipid metabolism, we have investigated whether choline or cytidine-5'-diphosphate choline, a choline donor, alters serum lipid responses to endotoxin in dogs and rats. In response to endotoxin, serum concentrations of triglycerides, choline-containing phospholipids, total cholesterol, and high-density lipoprotein cholesterol increased in a dose- and time-related manner. Administration of choline (20 mg/kg i.v. in dogs or 90 mg/kg i.p. in rats) or cytidine-5'-diphosphate choline (70 mg/kg i.v. in dogs) 5 min before and 4 and 8 h after endotoxin blocked or attenuated the increases in serum triglycerides, total cholesterol, and nonesterified fatty acids. Endotoxin-induced elevations in serum phospholipid levels did not change in rats and were enhanced in dogs by choline. In rats, serum lipid response to endotoxin was accompanied by severalfold elevations in serum levels of hepatorenal injury markers; their elevations were also blocked by choline. Pretreatment with hexamethonium blocked choline's effects on serum lipids and hepatorenal injury markers. Pretreatment with atropine blocked endotoxin-induced elevations in serum lipid and hepatorenal injury markers, but failed to alter choline's actions on these parameters. Choline treatment improved survival rate of rats in lethal endotoxin shock. In conclusion, these data show that choline treatment alters serum lipid responses to endotoxin and prevents hepatorenal injury during endotoxemia through a nicotinic acetylcholine receptor-mediated mechanism. Hence, choline and choline-containing compounds may have a therapeutic potential in the treatment of endotoxemia/sepsis. | en_US |
dc.description.sponsorship | Turkish Academy of Sciences European Commission (TUBA) | en_US |
dc.identifier.citation | İlçöl, Y. Ö. vd. (2009). "Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors". Shock, 32(3), 286-294. | en_US |
dc.identifier.endpage | 294 | tr_TR |
dc.identifier.issn | 1073-2322 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.pubmed | 19060783 | tr_TR |
dc.identifier.scopus | 2-s2.0-69549096230 | tr_TR |
dc.identifier.startpage | 286 | tr_TR |
dc.identifier.uri | https://doi.org/10.1097/SHK.0b013e3181971b02 | |
dc.identifier.uri | https://journals.lww.com/shockjournal/Fulltext/2009/09000/CHOLINE_OR_CDP_CHOLINE_ALTERS_SERUM_LIPID.10.aspx | |
dc.identifier.uri | http://hdl.handle.net/11452/22973 | |
dc.identifier.volume | 32 | tr_TR |
dc.identifier.wos | 000269226000010 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.relation.bap | V-2003/86 | tr_TR |
dc.relation.journal | Shock | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | CDP-choline | en_US |
dc.subject | Choline | en_US |
dc.subject | Dog | en_US |
dc.subject | Endotoxin | en_US |
dc.subject | Hypertriglyceridemia | en_US |
dc.subject | LPS | en_US |
dc.subject | Rat | en_US |
dc.subject | Serum lipids | en_US |
dc.subject | Serum phospholipids | en_US |
dc.subject | Tumor-necrosis-factor | en_US |
dc.subject | Increases | en_US |
dc.subject | Lipoproteins | en_US |
dc.subject | Metabolites | en_US |
dc.subject | Release | en_US |
dc.subject | Hypertriglyceridemia | en_US |
dc.subject | Augments | en_US |
dc.subject | Insulin | en_US |
dc.subject | System | en_US |
dc.subject | Shock | en_US |
dc.subject | General & internal medicine | en_US |
dc.subject | Hematology | en_US |
dc.subject | Surgery | en_US |
dc.subject | Cardiovascular system & cardiology | en_US |
dc.subject.emtree | Atropine | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Citicoline | en_US |
dc.subject.emtree | Endotoxin | en_US |
dc.subject.emtree | Fatty acid derivative | en_US |
dc.subject.emtree | Hexamethonium | en_US |
dc.subject.emtree | Low density lipoprotein cholesterol | en_US |
dc.subject.emtree | Nicotinic receptor | en_US |
dc.subject.emtree | Triacylglycerol | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Cholesterol blood level | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Endotoxemia | en_US |
dc.subject.emtree | Experimental dog | en_US |
dc.subject.emtree | Kidney injury | en_US |
dc.subject.emtree | Lipid metabolism | en_US |
dc.subject.emtree | Liver injury | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Septic shock | en_US |
dc.subject.emtree | Survival rate | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Atropine | en_US |
dc.subject.mesh | Cholesterol | en_US |
dc.subject.mesh | Choline | en_US |
dc.subject.mesh | Cytidine diphosphate choline | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endotoxins | en_US |
dc.subject.mesh | Fatty acids, nonesterified | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hexamethonium | en_US |
dc.subject.mesh | Kidney | en_US |
dc.subject.mesh | Lipid metabolism | en_US |
dc.subject.mesh | Lipids | en_US |
dc.subject.mesh | Liver | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Nicotinic antagonists | en_US |
dc.subject.mesh | Phospholipids | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, wistar | en_US |
dc.subject.mesh | Receptors, nicotinic | en_US |
dc.subject.mesh | Shock, septic | en_US |
dc.subject.mesh | Triglycerides | en_US |
dc.subject.scopus | Citicoline; Neuroprotective Agents; Glycerylphosphorylcholine | en_US |
dc.subject.wos | Critical care medicine | en_US |
dc.subject.wos | Hematology | en_US |
dc.subject.wos | Surgery | en_US |
dc.subject.wos | Peripheral vascular disease | en_US |
dc.title | Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |
dc.wos.quartile | Q1 (Surgery) | en_US |