The expression of common fragile sites and genetic predisposition to squamous cell lung cancers

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dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorÖzyardımcı, Nihat
dc.contributor.departmentUludağ Üniversitesi/Fen Edebiyat Fakültesi/Moleküler Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0002-9027-1132tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.date.accessioned2021-07-05T11:29:07Z
dc.date.available2021-07-05T11:29:07Z
dc.date.issued1997
dc.description.abstractThe chromosomal aberration rates (including gaps and breaks) and expression frequency of fragile sites were determined in peripheral blood lymphocytes cultured with TC 199 medium from 8 patients with squamous cell lung cancer, 10 of their first-degree relatives, and 12 healthy control subjects. As a result of cytogenetic evaluation, both the chromosomal aberration rates and expression frequencies of common fragile sites observed in patients and their relatives were significantly higher than those in healthy control subjects. Our results showed that common fragile sites might be unstable factors in the human genome, and their expression might be affected by some genetic and environmental factors. As a result of this they might play an important role in genetic predisposition to lung cancer. The high expression of fra(3)(p14) in patients and their relatives may be a valid marker for genetic predisposition to lung cancer.en_US
dc.identifier.citationEgeli, Ü. vd. (1997). "The expression of common fragile sites and genetic predisposition to squamous cell lung cancers". Cancer Genetics and Cytogenetics, 95(2), 153-158.en_US
dc.identifier.endpage158tr_TR
dc.identifier.issn0165-4608
dc.identifier.issue2tr_TR
dc.identifier.pubmed9169033tr_TR
dc.identifier.scopus2-s2.0-0031010323tr_TR
dc.identifier.startpage153tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0165-4608(96)00215-4
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165460896002154
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/9169033/
dc.identifier.urihttp://hdl.handle.net/11452/21069
dc.identifier.volume95tr_TR
dc.identifier.wosA1997XA83100006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.journalCancer Genetics and Cytogeneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectChromosome breakpointsen_US
dc.subjectAphidicolinen_US
dc.subjectLymphocytesen_US
dc.subjectRegionen_US
dc.subject.wosOncologyen_US
dc.subject.wosGenetics & heredityen_US
dc.titleThe expression of common fragile sites and genetic predisposition to squamous cell lung cancersen_US
dc.typeArticle

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