Major depressive disorder is accompanied with oxidative stress: Short-term antidepressant treatment does not alter oxidative-antioxidative systems

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dc.contributor.buuauthorSarandöl, Aslı
dc.contributor.buuauthorSarandöl, Emre
dc.contributor.buuauthorEker, Saygın Salih
dc.contributor.buuauthorErdinç, Selda
dc.contributor.buuauthorVatansever, Ebru
dc.contributor.buuauthorKirli, Selçuk
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.researcheridQ-9477-2019tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.scopusid14020405100tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.contributor.scopusid14019347700tr_TR
dc.contributor.scopusid24334883200tr_TR
dc.contributor.scopusid16070622700tr_TR
dc.contributor.scopusid14019745700tr_TR
dc.date.accessioned2022-05-23T05:41:26Z
dc.date.available2022-05-23T05:41:26Z
dc.date.issued2007-03
dc.description.abstractObjective The aim of the present study was to investigate the oxidative-antioxidative systems and effects of different antidepressants on these systems in patients with major depressive disorder (MDD). Method Ninety-six patients with a Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) diagnosis of MDD and 54 healthy controls were included in the study. Plasma malondialdehyde (MDA) levels and susceptibility of red blood cells (RBCs) to oxidation were determined to investigate the oxidative status, plasma vitamin E, vitamin C, serum total carotenoid levels, total antioxidant capacity (TAOC), RBC superoxide dismutase (SOD) and whole blood glutathione peroxidase (GPx) activities were measured to investigate the antioxidative defence before and after 6 weeks of antidepressant treatment. Results Plasma MDA levels and susceptibility of RBCs to oxidation were significantly higher in the MDD group compared with the control group. RBC SOD activity was significantly increased in patients with MDD, and furthermore there was a significant positive correlation between the severity of the disease and SOD activity. Conclusion MDD is accompanied with oxidative stress; however, oxidative-antioxidative systems do not seem to be affected by 6 weeks of antidepressant treatment.en_US
dc.identifier.citationSarandöl, A. vd. (2007). "Major depressive disorder is accompanied with oxidative stress: Short-term antidepressant treatment does not alter oxidative-antioxidative systems". Human Psychopharmacology-Clinical and Experimental, 22(2), 67-73.en_US
dc.identifier.endpage73tr_TR
dc.identifier.issn1099-1077
dc.identifier.issue2tr_TR
dc.identifier.pubmed17299810tr_TR
dc.identifier.scopus2-s2.0-33947726165tr_TR
dc.identifier.startpage67tr_TR
dc.identifier.urihttps://doi.org/10.1002/hup.829
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/hup.829
dc.identifier.urihttp://hdl.handle.net/11452/26592
dc.identifier.volume22tr_TR
dc.identifier.wos000245440800001tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalHuman Psychopharmacology-Clinical And Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidepressant treatmenten_US
dc.subjectLipid-peroxidationen_US
dc.subjectDamageen_US
dc.subjectNitric-oxideen_US
dc.subjectSerum vitaminen_US
dc.subjectLow-densityen_US
dc.subjectPlasmaen_US
dc.subjectMajor depressive disorderen_US
dc.subjectOxidative stressen_US
dc.subjectReboxetineen_US
dc.subjectSertralineen_US
dc.subjectVenlafaxineen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectPsychiatryen_US
dc.subjectPsychologyen_US
dc.subject.emtreeDiagnostic and statistical manual of mental disordersen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAntioxidant activityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeVitamin blood levelen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeDrug dose increaseen_US
dc.subject.emtreeErythrocyte levelen_US
dc.subject.emtreeShort course therapyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreeMajor depressionen_US
dc.subject.emtreeMaleen_US
dc.subject.meshAdulten_US
dc.subject.meshAntidepressive agentsen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshAscorbic aciden_US
dc.subject.meshCarotenoidsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshDepressive disorder, majoren_US
dc.subject.meshOxidative stressen_US
dc.subject.meshErythrocytesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione peroxidaseen_US
dc.subject.meshMaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshSuperoxide Dismutaseen_US
dc.subject.meshTime factorsen_US
dc.subject.meshUric aciden_US
dc.subject.meshVitamin Een_US
dc.subject.scopusSchizophrenia; Acetylcysteine; Bipolar Disorderen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.subject.wosPsychiatryen_US
dc.subject.wosPsychologyen_US
dc.titleMajor depressive disorder is accompanied with oxidative stress: Short-term antidepressant treatment does not alter oxidative-antioxidative systemsen_US
dc.typeArticle
dc.wos.quartileQ2 (Clinical neurology)en_US
dc.wos.quartileQ2 (Psychology)en_US
dc.wos.quartileQ3en_US

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