Thyroid hormones and growth in health and disease

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dc.contributor.buuauthorTarım, Ömer Faruk
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatrik Endokrinoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid6701427186tr_TR
dc.date.accessioned2021-12-14T07:29:17Z
dc.date.available2021-12-14T07:29:17Z
dc.date.issued2011-06
dc.description.abstractThyroid hormones regulate growth by several mechanisms. In addition to their negative feedback effect on the stimulatory hormones thyrotropin-releasing hormone (TRH) and thyrotropin (TSH), thyroid hormones also regulate their receptors in various physiological and pathological conditions. Up-regulation and down-regulation of the thyroid receptors fine-tune the biological effects exerted by the thyroid hormones. Interestingly, the deiodinase enzyme system is another intrinsic regulator of thyroid physiology that adjusts the availability of thyroid hormones to the tissues, which is essential for normal growth and development. Almost all chronic diseases of childhood impair growth and development. Every disease may have a unique mechanism to halt linear growth, but reduced serum concentration or diminished local availability of thyroid hormones seems to be a common pathway. Therefore, the effects of systemic diseases on thyroid physiology must be taken into consideration in the evaluation of growth retardation in affected children.en_US
dc.identifier.citationTarım, O. (2011). "Thyroid hormones and growth in health and disease". Journal of Clinical Research in Pediatric Endocrinology, 3(2), 51-55.en_US
dc.identifier.endpage55tr_TR
dc.identifier.issn1308-5727
dc.identifier.issue2tr_TR
dc.identifier.pubmed21750631tr_TR
dc.identifier.scopus2-s2.0-79959256520tr_TR
dc.identifier.startpage51tr_TR
dc.identifier.urihttps://doi.org/10.4274/jcrpe.v3i2.11
dc.identifier.urihttps://cms.galenos.com.tr/Uploads/Article_89/JCRPE-3-51-En.pdf
dc.identifier.urihttp://hdl.handle.net/11452/23232
dc.identifier.volume3tr_TR
dc.identifier.wos000497376200002tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosBKCISen_US
dc.language.isoenen_US
dc.publisherGalenos Yayıncılıktr_TR
dc.relation.journalJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectPediatricsen_US
dc.subjectThyroiden_US
dc.subjectGrowthen_US
dc.subjectChildrenen_US
dc.subject.emtreeIodide peroxidaseen_US
dc.subject.emtreeProtirelinen_US
dc.subject.emtreeProtirelin receptoren_US
dc.subject.emtreeThyroid hormoneen_US
dc.subject.emtreeThyroid hormone receptoren_US
dc.subject.emtreeThyrotropinen_US
dc.subject.emtreeThyrotropin receptoren_US
dc.subject.emtreeChilden_US
dc.subject.emtreeChild growthen_US
dc.subject.emtreeChildhood diseaseen_US
dc.subject.emtreeChronic diseaseen_US
dc.subject.emtreeGrowth retardationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeNegative feedbacken_US
dc.subject.emtreeReceptor down regulationen_US
dc.subject.emtreeReceptor upregulationen_US
dc.subject.emtreeRegulatory mechanismen_US
dc.subject.emtreeReviewen_US
dc.subject.emtreeSystemic diseaseen_US
dc.subject.emtreeThyroid hormone blood levelen_US
dc.subject.meshChilden_US
dc.subject.meshGrowthen_US
dc.subject.meshGrowth disordersen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidismen_US
dc.subject.meshKidney diseasesen_US
dc.subject.meshLiver diseasesen_US
dc.subject.meshMalnutritionen_US
dc.subject.meshMental disordersen_US
dc.subject.meshObesityen_US
dc.subject.meshThyroid hormonesen_US
dc.subject.scopusIodide Peroxidase; Iodothyronine Deiodinase Type II; Thyroid Hormonesen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.subject.wosPediatricsen_US
dc.titleThyroid hormones and growth in health and diseaseen_US
dc.typeReview
dc.typeBook Chapter

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