IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

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dc.contributor.authorJutel, Marek
dc.contributor.authorAkdis, M.
dc.contributor.authorAebischer-Casaulta, C.
dc.contributor.authorWrzyszcz, Maria
dc.contributor.authorBlaser, Kim M.
dc.contributor.authorAkdis, Cezmi A.
dc.contributor.buuauthorBudak, Ferah
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.date.accessioned2021-06-22T09:05:11Z
dc.date.available2021-06-22T09:05:11Z
dc.date.issued2003-02-19
dc.description.abstractThe regulation of normal and allergic immune responses to airborne allergens in the mucosa is still poorly understood, and the mechanism of specific immunotherapy (SIT) in normalizing the allergic response to such allergens is currently not clear. Accordingly, we have investigated the immunoregulatory mechanism of both normal and allergic responses to the major house-dust mite (HDM) and birch pollen allergens - Dermatophagoides pteroynyssinus (Der p)1 and Bet v 1, respectively - as well as the immunologic basis of SIT to HDM in rhinitis and asthma patients. In normal immunity to HDM and birch pollen, an allergen-specific peripheral T cell suppression to Der p 1 and Bet v 1 was observed. The deviated immune response was characterized by suppressed proliferative T cell and Th1 (IFN-gamma) and Th2 (IL-5, IL-13) cytokine responses, and increased IL-10 and TGF-beta secretion by allergen-specific T cells. Neutralization of cytokine activity showed that T cell suppression was induced by IL-10 and TGF-beta during SIT and in normal immunity to the mucosal allergens. In addition, SIT induced an antigen-specific suppressive activity in CD4(+) CD25(+) T cells of allergic individuals. Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens.en_US
dc.description.sponsorshipSwiss National Foundationen_US
dc.description.sponsorshipPolish National Science Committeeen_US
dc.description.sponsorshipSilva Casa Foundationen_US
dc.identifier.citationJutel, M. vd. (2003). “IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy”. European Journal of Immunology, 33(5), 1205-1214.tr_TR
dc.identifier.endpage1214tr_TR
dc.identifier.issn0014-2980
dc.identifier.issue5tr_TR
dc.identifier.pubmed12731045tr_TR
dc.identifier.scopus2-s2.0-0038363534tr_TR
dc.identifier.startpage1205tr_TR
dc.identifier.urihttps://doi.org/10.1002/eji.200322919
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/eji.200322919
dc.identifier.urihttp://hdl.handle.net/11452/20711
dc.identifier.volume33tr_TR
dc.identifier.wos000182961100008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalEuropean Journal of Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpecific immunotherapyen_US
dc.subjectT cellen_US
dc.subjectIL-10en_US
dc.subjectTGF-betaen_US
dc.subjectRegulatory T cellen_US
dc.subjectGrowth-factor-betaen_US
dc.subjectBee venom immunotherapyen_US
dc.subjectPhospholipase A(2)en_US
dc.subjectInterferon-gammaen_US
dc.subjectIge-synthesisen_US
dc.subjectHelper-cellsen_US
dc.subjectIn-vitroen_US
dc.subjectExpressionen_US
dc.subjectInductionen_US
dc.subjectToleranceen_US
dc.subject.wosImmunologyen_US
dc.titleIL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapyen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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