Romatoid artritte B hücre hedefli tedaviler
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Date
2011-09-22
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Uludağ Üniversitesi
Abstract
Romatoid artrit (RA), sıklıkla simetrik poliartikuler tutulumla karakterize kronik, sistemik, inflamatuar bir hastalıktır. Uygun tedavi edilmediği takdirde önemli ölçüde morbidite ve mortaliteye neden olabilir. Son on yılda RA etyopatogenezi ve tedavisinde büyük gelişmeler yaşanmıştır. Tümör nekroz faktör alfa inhibitörleriyle başlayan biyolojik ajanlar ve yakın geçmişte B hücre hedefleyen ajanların kullanımı RA tedavisinde yeni bir çağ açmıştır.
Rheumatoid arthritis (RA), is a chronic, systemic, inflammatory disease with usually symetric polyarticular involvement. In term of inadequate therapies it leads to substantial morbidity and mortality. Last ten years, there are great developments in the etiopathogenesis and treatment of RA. Biologic agents starting with tumor necrosis factor alpha inhibitors and in recent years, B cell targeted therapies opened a new era in the treatment of patients with RA.
Rheumatoid arthritis (RA), is a chronic, systemic, inflammatory disease with usually symetric polyarticular involvement. In term of inadequate therapies it leads to substantial morbidity and mortality. Last ten years, there are great developments in the etiopathogenesis and treatment of RA. Biologic agents starting with tumor necrosis factor alpha inhibitors and in recent years, B cell targeted therapies opened a new era in the treatment of patients with RA.
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Keywords
Rituksimab, Romatoid artrit, Ofatumumab, Ocralizumab, Rheumatoid Arthritis, B lenfosit, Ocralizumab, Rituksimab, B lymphocyte, Ofatumumab
Citation
Dalkılıç, E. ve Alkış, N. (2011). ''Romatoid artritte B hücre hedefli tedaviler''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 37(3), 161-164.