Relation between insulin resistance and serum concentrations of IL-6 and TNF-alpha in overweight or obese women with early stage breast cancer

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dc.contributor.buuauthorGönüllü, Güzin
dc.contributor.buuauthorErsoy, Canan
dc.contributor.buuauthorErsoy, Alpaslan
dc.contributor.buuauthorEvrensel, Türkkan
dc.contributor.buuauthorBaştürk, Bilkay
dc.contributor.buuauthorKurt, Ender
dc.contributor.buuauthorOral, Barboros
dc.contributor.buuauthorGökgöz, Şehsuvar
dc.contributor.buuauthorManavoğlu, Osman
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Romatoloji ve Nefroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-8784-1974tr_TR
dc.contributor.orcid0000-0002-9732-5340tr_TR
dc.contributor.orcid0000-0002-0710-0923tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.researcheridAAD-6918-2021tr_TR
dc.contributor.researcheridAAJ-1027-2021tr_TR
dc.contributor.researcheridAAH-5054-2021tr_TR
dc.contributor.researcheridAAH-8861-2021tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.scopusid6506410014tr_TR
dc.contributor.scopusid6701485882tr_TR
dc.contributor.scopusid35612977100tr_TR
dc.contributor.scopusid6603942124tr_TR
dc.contributor.scopusid55910304400tr_TR
dc.contributor.scopusid7006207332tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.contributor.scopusid6603238737tr_TR
dc.contributor.scopusid6602587152tr_TR
dc.date.accessioned2021-07-29T06:42:15Z
dc.date.available2021-07-29T06:42:15Z
dc.date.issued2005-08-21
dc.description.abstractInsulin resistance (IR) and obesity may be risk factors for breast cancer. The mechanism of IR in patients with cancer has not been fully clarified yet. This study was conducted to evaluate the possible role of circulating cytokines; tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) in inducing IR in 20 overweight or obese patients with early stage breast cancer and to compare their levels with that of body mass index matched 20 healthy controls. IR was calculated by homeostasis model assessment (HOMA) method. Four groups were formed according to a 2.7 HOMA-IR cut-off value as breast cancer with or without IR and controls with or without IR. IL-6 and HOMA-IR values were found to be higher in breast cancer patients with IR compared to other groups. There was no significant difference in TNF-alpha levels between groups. HOMA-IR values correlated with estradiol and IL-6 levels in all breast cancer patients but not TNF-alpha. HOMA-IR values, serum insulin, estradiol and IL-6 levels in the receptor positive group were significantly higher than those of the receptor negative group. These results suggested a possible contribution of endogenous IL-6 production and hyperinsulinemia to the development of breast cancer in overweight or obese patients with prominent IR.en_US
dc.identifier.citationGönüllü, G. vd. (2005). "Relation between insulin resistance and serum concentrations of IL-6 and TNF-alpha in overweight or obese women with early stage breast cancer". Cytokine, 31(4), 264-269.en_US
dc.identifier.endpage269tr_TR
dc.identifier.issn1043-4666
dc.identifier.issue4tr_TR
dc.identifier.pubmed15955709tr_TR
dc.identifier.scopus2-s2.0-23244440328tr_TR
dc.identifier.startpage264tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2005.05.003
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1043466605001602
dc.identifier.urihttp://hdl.handle.net/11452/21323
dc.identifier.volume31tr_TR
dc.identifier.wos000231330300003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Scienceen_US
dc.relation.journalCytokineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectInsulin resistanceen_US
dc.subjectObesityen_US
dc.subjectTNF-alphaen_US
dc.subjectIL-6en_US
dc.subjectTumor-necrosis-factoren_US
dc.subjectPreventionen_US
dc.subjectRegulating estrogen synthesisen_US
dc.subjectBeta-cell functionen_US
dc.subjectCytokine receptorsen_US
dc.subjectHip-ratioen_US
dc.subjectInterleukin-6en_US
dc.subjectExpressionen_US
dc.subjectAdipocyteen_US
dc.subjectCorrelateen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectImmunologyen_US
dc.subjectCell biologyen_US
dc.subject.emtreeEstradiolen_US
dc.subject.emtreeInsulinen_US
dc.subject.emtreeInterleukin 6en_US
dc.subject.emtreeTumor necrosis factor alphaen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeCancer stagingen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGlucose homeostasisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInsulin resistanceen_US
dc.subject.emtreeMathematical computingen_US
dc.subject.emtreeObesityen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeProtein functionen_US
dc.subject.meshAdulten_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin resistanceen_US
dc.subject.meshInterleukin-6en_US
dc.subject.meshMiddle ageden_US
dc.subject.meshObesityen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshTumor necrosis factor-alphaen_US
dc.subject.scopusChildhood Cancer Survivor; Breast Cancer Survival; Breast Neoplasmsen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.subject.wosImmunologyen_US
dc.titleRelation between insulin resistance and serum concentrations of IL-6 and TNF-alpha in overweight or obese women with early stage breast canceren_US
dc.typeArticle
dc.wos.quartileQ3en_US

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