Fetal enflamatuar yanıt sendromu ve beyin zedelenmesi
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Date
2007
Authors
Kumral, Abdullah
Yeşilırmak, Didem Cemile
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Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Preterm doğuma ve neonatal komplikasyonlara neden olan faktörler içerisinde en sık saptanan nedenlerin baflında intrauterin enfeksiyonve/veya enflamasyon gelmektedir. Mikroorganizma veya ürünlerinin fetusa ulaflması sitokin salınıflına ve sistemik fetal enflamatuar cevaba (FIRS) neden olmaktadır. FIRS; fetal veya neonatal beyin hasarına neden olarak ileride serebral palsi (CP) geliflimine yol açmaktadır. İntrauterin dönemde sitokinlerin neden olacağı beyaz cevher hasarı ve preterm doğum ile CP arasındaki iliflki günümüzde iyi bilinmektedir. Klinikte karflımıza periventriküler lökomalazi (PVL) olarak çıkan beyaz cevher hasarı, nörogeliflimsel prognoz ve CP’nin ağırlığı açısından oldukça önemlidir
Intrauterine infection/inflammation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS (Fetal Inflammatory Response Syndrome). Subsequently, FIRS was implicated as a cause of fetal or neonatal brain injury that leads to cerebral palsy (CP). A relationship between CP and intra-amniotic inflammation was demonstrated, intrauterine infection may lead to activation of the cytokine network which in turn can cause white matter brain damage and preterm delivery, as well and as the future development of CP. This white matter insult is identified clinically as periventricular leucomalacia (PVL) which is associated with the subsequent development of impaired neurological outcomes of variable severity including CP.
Intrauterine infection/inflammation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS (Fetal Inflammatory Response Syndrome). Subsequently, FIRS was implicated as a cause of fetal or neonatal brain injury that leads to cerebral palsy (CP). A relationship between CP and intra-amniotic inflammation was demonstrated, intrauterine infection may lead to activation of the cytokine network which in turn can cause white matter brain damage and preterm delivery, as well and as the future development of CP. This white matter insult is identified clinically as periventricular leucomalacia (PVL) which is associated with the subsequent development of impaired neurological outcomes of variable severity including CP.
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Keywords
Fetal enflamatuar yanıt sendromu, Beyin hasarı, Fetal inflammatory response syndrome, Brain injury
Citation
Kumral, A. ve Yeşilırmak, D. C. (2007). "Fetal enflamatuar yanıt sendromu ve beyin zedelenmesi". Güncel Pediatri, 5(1), 25-27.