Fluconazole treatment of neonates and infants with severe fungal infections
Date
1997
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications
Abstract
A total of 24 neonates and infants, aged from 2 days to 10 months, received treatment with intravenous fluconazole for microbiologically documented or presumed fungal infection. The mean fluconazole dosage was 6 mg/kg/day (range 2 -16 mg/kg/day) and the mean duration of therapy was 25 days (range 5 - 72 days). Efficacy was evaluated in neonates with proven fungal infections, as documented by the presence of pathogen at baseline. A positive clinical response was achieved in 23 of the 24 clinically evaluable patients (96%); eradication of the fungal organism was also achieved in 23 of the 24 evaluable patients (96%). Adverse events occurred in two patients (8%) but therapy was not discontinued in either patient. The present results confirm the efficacy and safety of fluconazole in the treatment of neonates and infants with severe fungal infections.
Description
Keywords
Research & experimental medicine, Pharmacology & pharmacy, Fluconazole, Antifungal therapy, Candida albicans, Fungal infection, Neonate, Infant
Citation
Gürpınar, A. N. vd. (1997). "Fluconazole treatment of neonates and infants with severe fungal infections". Journal of International Medical Research, 25(4), 214-218.