A new Synthesis of n-substituted-1,2,3,4-tetrahydro-4-phenylisoquinolin-3-ones

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Date

1993

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Journal ISSN

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Publisher

Marcel Dekker Inc

Abstract

1,2,3,4-Tetrahydro-4-phenylisoquinolin-3-ones 3 are obtained from appropriate N,N-disubstituted phenylacetamides 1, using lead tetraacetate ( LTA ) as oxidant and Lewis or proton acids as cyclizing agents. The methods for this conversion could be one stage ( method B or C ), or two stages ( method A ). The latter method was particularly developed to explain the mechanism of the reaction.

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Keywords

Chemistry, 4-Aryl, Tetrahydroisoquinolines, Disubstituted

Citation

Coşkun, N. ve Sümengen, D. (1993). ''A New Synthesis of N-Substituted-1,2,3,4-tetrahydro-4-phenylisoquinolin-3-ones''. Synthetic Communications, 23(10), 1393-1402.

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