Browsing by Author "Van Diepeningen, Anne D."
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Item Emergence of fusarioses in a university hospital in Turkey during a 20-year period(Springer, 2015-08) Al-Hatmi, Abdullah M.S.; Seyedmousavi, Seyedmojtaba; Rijs, Antonius J.M.M.; Verweij, Paul E.; De Hoog, Gerrit Sybren; Van Diepeningen, Anne D.; Cilo, Burcu Dalyan; Ener, Beyza; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.; 0000-0002-4803-8206; AAG-8523-2021; 36620979500; 15053025300Fusarium species have started appearing increasingly as the main cause of infections, particularly in immunocompromised patients. In this study, we aimed to present the first epidemiological data from Turkey, analyze fusariosis cases that have been monitored in a university hospital during the past 20 years, identify the responsible Fusarium species, and determine antifungal susceptibilities. A total of 47 cases of fusariosis was included in the study. Fusarium isolates were identified by multilocus sequence typing (MLST). Antifungal susceptibility was tested by the broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) methodology. Of the Fusarium infections, 23.4 % were superficial, 44.7 % were locally invasive, and 31.9 % were disseminated. A significant increase was observed over the years. The Fusarium fujikuroi species complex (FFSC) proved to be the most frequent agent group (17 cases; 51.5 %), followed by the Fusarium solani species complex (FSSC) (14 cases; 42.4 %), the Fusarium dimerum species complex (FDSC), and the Fusarium oxysporum species complexes (FOSC) (one case each). Amphotericin B had the highest in vitro activity against all species. Voriconazole and posaconazole showed interspecies variability across and within Fusarium species complexes. In conclusion, our data support the fact that regional differences exist in the distribution of the Fusarium species and that species-specific differences are observed in antifungal susceptibility patterns. The monitoring of local epidemiological data by determining fungal identity and susceptibility are of importance in guiding the clinical follow-up of patients.Item Fatal break-through infection with Fusarium andiyazi: New multi-resistant etiological agent cross-reacting with Aspergillus galactomannan enzyme immunoassay(Wiley, 2013-10) Van Diepeningen, Anne D.; Meijer, Martin; Al Hatmi, Abdullah M. S.; Kebabçı, Nesrin; Ener, Beyza; Ersal, Tuba; Özkocaman, O.; Ursavaş, Ahmet; Çetinoğlu, Ezgi Demirdöğen; Akalı, H.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0002-4803-8206; AAI-3169-2021; AAG-8523-2021; AAJ-4354-2021Item Multilocus microsatellite analysis of European and African Candida glabrata isolates(Springer, 2016-02-15) Chillemi, Valeria; Lo Passo, Carla; Van Diepeningen, Anne D.; Rharmitt, Sanae; Delfino, Demetrio; Cascio, Antonio; Nnadi, Nnaemeka Emmanuel; Sampaio, Paula; Tietz, Hans-Juergen; Peman, Javier; Criseo, Giuseppe; Romeo, Orazio; Scordino, Fabio; Cilo, Burcu Dalyan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.; 56364338600This study aimed to elucidate the genetic relatedness and epidemiology of 127 clinical and environmental Candida glabrata isolates from Europe and Africa using multilocus microsatellite analysis. Each isolate was first identified using phenotypic and molecular methods and subsequently, six unlinked microsatellite loci were analyzed using automated fluorescent genotyping. Genetic relationships were estimated using the minimum-spanning tree (MStree) method. Microsatellite analyses revealed the existence of 47 different genotypes. The fungal population showed an irregular distribution owing to the over-representation of genetically different infectious haplotypes. The most common genotype was MG-9, which was frequently found in both European and African isolates. In conclusion, the data reported here emphasize the role of specific C. glabrata genotypes in human infections for at least some decades and highlight the widespread distribution of some isolates, which seem to be more able to cause disease than others.