Browsing by Author "Mistik, Reşit"
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Publication Chronic granulomatous disease diagnosed in adulthood(Turkish Soc Immunology, 2015-12-01) Karakeçili, Faruk; Akın, Hicran; Pekgöz, Murat; Mistik, Reşit; Oral, Haluk Barboros; ORAL, HALUK BARBAROS; Akalın, Halis; AKALIN, EMİN HALİS; Bursa Uludağ Üniversitesi/Tıp Fakültesi/ Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-7368-7187; 0000-0003-0463-6818; 0000-0001-7530-1279; AAU-8952-2020; K-7285-2012Chronic granulomatous disease (CGD) is a rare, genetically heterogeneous disease characterized by severe infections that can be life threatening. The disease develops due to defects in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system. It is characterized by granuloma formation depending on recurrent infections and increased inflammatory response. Lung, skin, lymph nodes, and liver are the most involved organs. Nitroblue tetrazolium test (NBT) is the most frequently used test in screening. In this article, a chronic granulomatous disease case diagnosed in adulthood and having recurrent liver and lung abscesses is reported in light of the literature. A 22-year-old male patient was admitted to our polyclinic with high fever for two weeks. Patient's family history was received in terms of CGD and NBT was carried out. Patient's NBT result was negative (0%) twice. The patient was administered empiric ceftriaxone and metronidazole treatment. Abscess drainage was planned for the patient diagnosed as CGD as a result of the analyses. The patient who developed fever response and whose laboratory values improved was discharged proposing polyclinic control with trimethoprim/ sulfamethoxazole and itraconazole prophylaxis. This case indicates that, although rarely, CGD might be diagnosed in adulthood in our country where consanguineous marriage and hereditary diseases are common.Publication Fatal cryptococcal meningitis in a patient with chronic lymphocytic leukemia(Pagepress Publ, 2012-01-01) Dizdar, Oğuzhan Sıtkı; Karakeçili, Faruk; Coşkun, Belkıs Nihan; COŞKUN, BELKIS NİHAN; Ener, Beyza; ENER, BEYZA; Ali, Rıdvan; ALİ, RIDVAN; Mistik, Reşit; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Hemotoloji Anabilim Dalı.; D-6213-2013; AAG-8523-2021; AAG-7155-2021Patients with chronic lymphocytic leukemia (CLL) are susceptible to infections, especially opportunistic infections. We have described a patient with CLL who had cryptococcal meningitis. Despite lack of previous immunosuppressive treatment history, the patient experienced serious and fatal fungal infection. Physicians should be alert for a diagnosis of cryptococcal meningitis in patient with CLL who developed fever and headache.Item Transfusion-transmitted virus infection in renal transplant recipients(Elsevier, 2002-12) Usta, Mine; Dilek, Keyser; Yavuz, M. S.; Mistik, Reşit; Heper, Yasemin; Güllülü, Mustafa; Burçin, Oktay; Ersoy, Alparslan; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; AAH-6506-2021; 7005030712; 6603823242; 35612977100; 6602564624; 6506103422; 6602684544; 7006244754; 6602172127; 7003389525The transfusion-transmitted virus (TTV) described recently was first detected in peripheral blood and liver tissue of symptomatic patients with posttransfusion hepatitis non A-G.1, 2 TTV is presumed to be an unenveloped, circular, negative stranded DNA virus containing a genome of 3852 bases. It is proposed that TTV is a member of a new virus family that infects humans, tentatively named the Circinoviridae.3 TTV infection in humans occurs worldwide, and its prevalence is regionally very different.4 It was first isolated from patients with posttransfusion hepatitis.2 Viremia may be transient or persistent, and viremic individuals are often asymptomatic. Its transmission occurs not only by blood transfusion, but also by non-parenteral infection.5 Renal transplant (RTx) recipients can be infected with TTV because of exposure to the frequent blood transfusions during hemodialysis treatments. However, not much data is available about TTV infection in renal transplant recipients.6, 7 Therefore, we investigated the prevalence of TTV and the relation to liver diseases in these populations.