Browsing by Author "Kutlay, Sim"
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Publication Characteristics and survival data of patients with primary focal segmental segmental glomerulosclerosis: Tsn-goldmulti-center study(Oxford Univ Press, 2023-06-01) Dheir, Hamad; Cebeci, Egemen; Karadağ, Serhat; Yıldız, Abdulmecit; Güller, Nurana; Altiparmak, Mehmet Riza; Eren, Necmi; Yilmaz, Zulfikar; Basturk, Taner; Sipahi, Savas; Sahin, Gulizar; Bakar, Betul; Okyay, Gulay Ulusal; Suleyman, Gultekin; Piskinpasa, Serhan Vahit; Dursun, Belda; Balal, Mustafa; Turgutalp, Kenan; Guzel, Fatma Betul; Kutlay, Sim; Tatar, Erhan; Elcioglu, Omer Celal; Karakan, Sebnem; Kayalar, Arzu Ozdemir; FarukAkcay, Omer; Yildirim, Tolga; Sahin, Idris; Sahin, Garip; Ogutmen, Melike Betul; Tokgoz, Bulent; Tunca, Onur; Gul, Cuma Bulent; Kurultak, Ilhan; Torun, Dilek; Ayar, Yavuz; Uzun, Sami; Yavuz, Mahmut; Oto, Ozgür Akın; Dinçer, Mevlüt Tamer; Ergül, Metin; Öztürk, Savaş; Türkmen, Aydın; YILDIZ, ABDULMECİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilin Dalı.; HIG-9032-2022Publication Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group(Springer, 2020-10-27) Şumnu, Abdullah; Türkmen, Kültigin; Cebeci, Egemen; Türkmen, Aydın; Eren, Necmi; Seyahi, Nurhan; Oruç, Ayşegül; Dede, Fatih; Derici, Ülver; Baştürk, Taner; Şahin, Garip; Sipahioğlu, Murat; Şahin, Gülizar Manga; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Sena; Güngör, Özkan; Kutlay, Sim; Bahçebaşı, Zerrin Bicik; Şahin, İdris; Kurultak, İlhan; Sevinç, Can; Yılmaz, Zülfikar; Kazancıoğlu, Rümeyza Turan; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Gül, Bülent; Altun, Bülent; Paydaş, Saime; Uzun, Sami; İstemihan, Zülal; Ergül, Metin; Dinçer, Mevlüt Tamer; Güllulü, Mustafa; Pişkinpaşa, Serhan; Akçay, Ömer Faruk; Ünsal, Abdulkadir; Koyuncu, Sümeyra; Gök, Mahmut; Öztürk, Savaş; ORUÇ, AYŞEGÜL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; AAH-4002-2021; CTG-8811-2022Purpose Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. Methods Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. Results Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). Conclusion This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.Publication Demographic and clinical characteristics of primary glomerular diseases in Turkey(Springer, 2014-12-01) Öztürk, Savaş; Sumnu, Abdullah; Seyahi, Nurhan; Sipahioglu, Murat; Artan, Serra; Bicik, Zerrin; Kutlay, Sim; Keles, Mustafa; Oygar, Deren; Odabas, Ali Riza; Kayatas, Mansur; Dursun, Belda; Sayarlioglu, Hayriye; Trablus, Sinan; Taymez, Dilek Guven; Özdemir, Ali Abbas; Sahin, Gulizar Manga; Altun, Bulent; Azak, Alper; Altıntepe, Lutfullah; Suleymanlar, Gultekin; Koc, Mehmet; Selcuk, Yilmaz; Kazancıoğlu, Rumeyza; Erkoç, Reha; Gursu, Meltem; Küçük, Mehmet; Akçaoglu, Selma Alagöz; Yıldız, Abdulmecid; Ünal, Aydın; Akarsu, Özger; Ates, Kenan; Cankaya, Erdem; Türkmen, Aydın; Güllülü, Mustafa; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.The aim of our study was to delineate the demographic and clinical properties of primary glomerular diseases of adult population in our country in the light of global knowledge.All over the country, a total of 25 centers entered data between May 2009 and July 2012 to the database created by 'Glomerulonephritis Study Group' of Turkish Society of Nephrology. Demographic and clinical characteristics, specific diagnoses of glomerular diseases and biopsy findings recorded to the database were analyzed.Among the 1,274 patients, who had renal biopsy within the defined time period, 55 % were male and 45 % were female. The mean age was 40.8 +/- A 14.6 years. The most frequent indication for biopsy was nephrotic syndrome (57.8 %), followed by nephritic syndrome including rapidly progressive glomerulonephritis (16.6 %) and asymptomatic urinary abnormalities (10.8 %). The most frequent primary glomerular disease was membranous nephropathy (28.8 %), followed by focal segmental glomerulosclerosis (19.3 %) and IgA nephropathy (17.2 %).The presented study displayed important data about the epidemiology of primary glomerular diseases among adults in our country. The predominance of membranous nephropathy in contrast to other countries, in which the most frequent etiology is IgA nephropathy, seems to be due to differences in the indications for renal biopsy.Publication Demographic and clinical characteristics of rapidly progressive glomerulonephritis in Turkey(Oxford Univ Press, 2020-06-01) Aydın, Zeki; Türkmen, Kultiğin; Dede, Fatih; Yaşar, Emre; Öztürk, Savaş; Tatar, Erhan; Şahin, Garip; Şahin, Gülizar Manga; Oto, Özgür Akın; Sumnu, Abdullah; Eroğlu, Eray; Dinçer, Mevlüt Tamer; Dursun, Belda; Eren, Necmi; Sevinç, Mustafa; Güzel, Fatma Betül; Yalın, Serkan Feyyaz; Kutlay, Sim; Apaydın, Süheyla; Berktaş, Hacı Bayram; Kazan, Sinan; Dheir, Hamad; Bora, Feyza; Baştürk, Taner; Şahin, İdris; Aydin, Mehmet; AYDIN, MEHMET AKİF; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-5665-7402; AAJ-8220-2020Publication Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group(Springer, 2020-09-29) Aydın, Zeki; Türkmen, Kültigin; Dede, Fatih; Yaşar, Emre; Öztürk, Savaş; Aydın, Mehmet; Tatar, Erhan; Şahin, Garip; Manga, Gülizar; Oto, Özgür; Şumnu, Abdullah; Eroğlu, Eray; Dinçer, Tamer; Dursun, Belda; Eren, Necmi; Sevinç, Mustafa; Güzel, Fatma Betül; Yalın, Serkan; Kutlay, Sim; Apaydın, Süheyla; Berktaş, Hacı Bayram; Kazan, Sinan; Dheir, Hamad; Bora, Feyza; Baştürk, Taner; Sahin, Idris; AYDIN, MEHMET AKİF; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Nefroloji Bilim Dalı.; 0000-0002-5665-7402; AAJ-8220-2020Background In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune). Results Of 3875 patients, 200 patients with RPGN (mean age 47.9 +/- 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9-5.7) mg/dl, glomerular filtration rate was 18 (10-37) ml/min/1.73m(2)and proteinuria 2100 (1229-3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusions Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.Publication Epidemiological and clinical characterstics of iga nephropathy patients in turkey: Tsn-gold working group(Oxford Univ Press, 2020-06-01) Eren, Necmi; Gürsu, Meltem; Cebeci, Egemen; Türkmen, Aydın; Yeter, Hasan Hacı; Seyahi, Nurhan; Pişkinpaşa, Serhan Vahit; Ersoy, Alpaslan; Baştürk, Taner; Şahin, Gülizar Manga; Yücel, Fatma Sibel Koçak; Genç, Ahmed Bilal; Şahin, Garip; Ulu, Memnune Sena; Soyhan, Merve; Türkmen, Kültigin; Özberk, Sümeyra; Elcioglu, Omer; Altunören, Orçun; Şahin, İdris; Kutlay, Sim; Ustündağ, Sedat; Kalender, Betül; Dede, Fatih; Altun, Bülent; Ersoy, Alpaslan; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021Publication Is the severity of glomerular igg staining in patient with iga nephropathy useful for predicting poor renal prognosis? The data from Tsn-gold working group(Oxford University Press, 2020-06-01) Turgutalp, Kenan; Cebeci, Egemen; Türkmen, Aydin; Derici, Ülver; Seyahi, Nurhan; Eren, Necmi; Dede, Fatih; Güllülü, Mustafa; Baştürk, Taner; Şahin, Gülizar Manga; Yılmaz, Mürvet; Sipahi, Savaş; Şahin, Garip; Ulu, Memnune Sena; Tatar, Erhan; Gündoğdu, Ali; Kazancıoğlu, Rümeyza Turan; Sevinç, Can; Güngör, Özkan; Şahin, İdris; Kutlay, Sim; Kurultak, İlhan; Aydın, Zeki; Altun, Bülent; Dursun, Belda; Yılmaz, Zülfikar; Uzun, Özcan; Süleymanlar, Gültekin; Candan, Ferhan; Sezer, Siren; Tanburoğlu, Derya Başak; Bahçebaşı, Zerrin Bicik; Taymez, Dilek Güven; Oygar, Deren; Akçalı, Esra; İstemihan, Zulal; Akçay, Ömer Faruk; Dinçer, Mevlüt Tamer; Ergül, Metin; Yenigün, Ezgi; Türkmen, Kültigin; Öztürk, Savaş; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; CTG-8811-2022Publication Membranous nephropathy in Turkey: Turkish society of nephrology glomeruler diseases (tsn-gold) database results(Oxford University Press, 2020-06-01) Yıldız, Abdülmecit; Ulu, Memnune Sena; Oruç, Ayşegül; Uçar, Ali Rıza; Öztürk, Savaş; Alagöz, Selma; Eren, Necmi; Koçyiğit, İsmail; Cevher, Simal Köksal; Haraş, Ali Burak; Sumnu, Abdullah; Arınsoy, Turgay; Şahin, Garip; Süleymanlar, Gültekin; Çavdar, Caner; Gahin, Gizem Kumru; Kurultak, İlhan; Ünsal, Abdülkadir; Şahin, Gülizar Manga; Kazan, Sinan; Vatansever, Bülent; Dikeç, Mehmet; Dursun, Belda; Sayarlıoğlu, Hayriye; Türkmen, Kultiin; Artan, Ayşe Serra; Aktaş, Nimet; Yılmaz, Zülfikar; Behlül, Ahmet; Dheir, Hamad; Kutlay, Sim; Seyahi, Nurhan; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-0342-9692; AAH-4002-2021; HIG-9032-2022Publication The relationship between glomerular igg staining and poor prognostic findings in patients with iga nephropathy: The data from tsn-gold working group(BMC, 2021-10-28) Turgutalp, Kenan; Cebeci, Egemen; Turkmen, Aydin; Derici, Ulver; Seyahi, Nurhan; Eren, Necmi; Dede, Fatih; Basturk, Taner; Sahin, Gulizar Manga; Yilmaz, Murvet; Sipahi, Savas; Sahin, Garip; Ulu, Sena; Tatar, Erhan; Gundogdu, Ali; Kazancioglu, Rumeyza Turan; Sevinc, Can; Gungor, Ozkan; Sahin, Idris; Kutlay, Sim; Kurultak, Ilhan; Aydin, Zeki; Altun, Bulent; Dursun, Belda; Yilmaz, Zulfikar; Uzun, Ozcan; Suleymanlar, Gultekin; Candan, Ferhan; Sezer, Siren; Tanburoglu, Derya Basak; Bahcebasi, Zerrin Bicik; Taymez, Dilek; Akcali, Esra; Oygar, Deren; Istemihan, Zulal; Bardak, Simge; Akcay, Omer Faruk; Dincer, Mevlut Tamer; Dervisoglu, Erkan; Yenigun, Ezgi; Turkmen, Kultigin; Ozturk, Savas; Güllülü, Mustafa; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0245-1844; 0000-0001-7427-618X; 0000-0002-2708-3470; 0000-0002-0409-2710; 0000-0001-6829-121X; 0000-0002-5068-4231; 0000-0002-9594-4121; 0000-0002-4069-9181; 0000-0002-8683-3737; 0000-0001-5607-1375; 0000-0002-6648-6053; 0000-0002-4017-0640; 0000-0002-6851-4871; 0000-0002-0961-3810; P-9618-2015; HKV-4703-2023; GRX-9954-2022; V-1616-2019; AAA-8435-2020; AFR-4244-2022; JYQ-2550-2024; S-7661-2016; AAS-4390-2020; Q-6320-2019; R-1388-2018Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.Publication The relationship between severity of interstitial fibrosis and anemia in patient with primary glomerulonephritis: The data from TSN-gold working group(Oxford Univ Press, 2020-06-01) Cebeci, Egemen; Turgutalp, Kenan; Öztürk, Savaş; Özlük, Yasemin; Bek, Sibel Gökçay; Şumnu, Abdullah; Seyahi, Nurhan; Yavuz, Mahmut; Pişkinpaşa, Serhan Vahit; Akçay, Ömer Faruk; Sakaci, Tamer; Şahin, Garip; Tokgöz, Bülent; Şahin, Gülizar Manga; Bozacı, Ilter; Dursun, Belda; Sipahi, Savaş; Kayalar, Arzu Özdemir; Süleymanlar, Gültekin; Ulu, Memnune Sena; Güzel, Fatma Betül; Kutlay, Sim; Parmaksız, Ergün; Koz, Süleyman; Kurultak, İlhan; Selçuk, Nedim Yılmaz; Yildırım, Yaşar; Gürsu, Meltem; Çavdar, Caner; Timuçin, Meryem; Aydın, Zeki; Oygar, Deren; Kahvecioğlu, Serdar; Kibar, Müge Uzerk; Torun, Dilek; Taymez, Dilek Güven; Küçük, Mehmet; Demir, Serap; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altintepe, Lüftullah; Koç, Mehmet; Azak, Alper; Odabaş, Ali Rıza; Yılmaz, Zülfikar; Paydaş, Saime; YAVUZ, MAHMUT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; EHM-7377-2022Publication Trends of primary glomerular disease in Turkey from 2009 to 2017: A regional registry report from tsn-gold working group(Oxford Univ, 2020-06-01) Gül, Cuma Bülent; Küçük, Mehmet; Öztürk, Savaş; Demir, Erol; Eren, Necmi; Süönü, Abdullah; Seyahi, Nurhan; Dede, Fatih; Derici, Ülver; Koç, Yener; Şahin, Garip; Oymak, Oktay; Şahin, Gulizar Manga; Tatar, Erhan; Dursun, Belda; Dheir, Hamad; Apaydın, Suheyla; Süleymanlar, Gültekin; Ulu, Memnune Sena; Altunören, Orçun; Kutlay, Sim; Meşe, Meral; Şahin, İdris; Üstündağ, Sedat; Türkmen, Kultiğin; Yılmaz, Mehmet Emin; Kazancıoğlu, Rümeyza Turan; Uzun, Özcan; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Aktaş, Nimet; Erdem, Yunus; Paydaş, Saime; Taymez, Dilek Güven; Can, Başak; Kiykim, Ahmet; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altıntepe, Lüftullah; Kaya, Burcu; Azak, Alper; Ecder, Sabahat Alışır; Cavdar, Caner; Selçuk, Nedim Yılmaz; Güllülü, Mustafa; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; CTG-8811-2022