Browsing by Author "Baştürk, Taner"
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Publication Amyloid a amyloidosis after renal transplantation: An important cause of mortality(Lippincott Williams & Wilkins, 2020-08-01) Sarıhan, İrem; Çalışkan, Yaşar; Mirioğlu, Şafak; Özlük, Yasemin; Senates, Banu; Seyahi, Nurhan; Baştürk, Taner; Yıldız, Abdulmecit; Kılıçaslan, Işin; Sever, Mehmet Şükrü; YILDIZ, ABDULMECİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Bölümü; HIG-9032-2022Background. There are limited data on the outcome of transplant recipients with familial Mediterranean fever (FMF)-associated AA amyloidosis. The aim of the present study is to evaluate demographic, clinical, laboratory, and prognostic characteristics and outcome measures of these patients. Methods. Eighty-one renal transplant recipients with FMF-associated AA amyloidosis (group 1) and propensity score-matched transplant recipients (group 2, n = 81) with nonamyloidosis etiologies were evaluated in this retrospective, multicenter study. Recurrence of AA amyloidosis was diagnosed in 21 patients (group 1a), and their features were compared with 21 propensity score-matched recipients with FMF amyloidosis with no laboratory signs of recurrence (group 1b). Results. The risk of overall allograft loss was higher in group 1 compared with group 2 (25 [30.9%] versus 12 [14.8%];P= 0.015 [hazard ratio, 2.083; 95% confidence interval, 1.126-3.856]). Patients in group 1 were characterized by an increased risk of mortality compared with group 2 (11 [13.6%] versus 0%;P= 0.001 [hazard ratio, 1.136; 95% confidence interval, 1.058-1.207]). Kaplan-Meier analysis revealed that 5- and 10-year patient survival rates in group 1 (92.5% and 70.4%) were significantly lower than in group 2 (100% and 100%;P= 0.026 andP= 0.023, respectively). Although not reaching significance, overall, 5- and 10-year graft survival rates (57.1%, 94.7%, and 53.8%, respectively) in group 1a were worse than in group 1b (76.2%, 95%, and 77.8%, respectively;P= 0.19,P= 0.95, andP= 0.27, respectively). Conclusions. AA amyloidosis is associated with higher risk of mortality after kidney transplantation. Inflammatory indicators should be monitored closely, and persistent high levels of acute-phase reactants should raise concerns about amyloid recurrence in allograft.Publication Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group(Springer, 2020-10-27) Şumnu, Abdullah; Türkmen, Kültigin; Cebeci, Egemen; Türkmen, Aydın; Eren, Necmi; Seyahi, Nurhan; Oruç, Ayşegül; Dede, Fatih; Derici, Ülver; Baştürk, Taner; Şahin, Garip; Sipahioğlu, Murat; Şahin, Gülizar Manga; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Sena; Güngör, Özkan; Kutlay, Sim; Bahçebaşı, Zerrin Bicik; Şahin, İdris; Kurultak, İlhan; Sevinç, Can; Yılmaz, Zülfikar; Kazancıoğlu, Rümeyza Turan; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Gül, Bülent; Altun, Bülent; Paydaş, Saime; Uzun, Sami; İstemihan, Zülal; Ergül, Metin; Dinçer, Mevlüt Tamer; Güllulü, Mustafa; Pişkinpaşa, Serhan; Akçay, Ömer Faruk; Ünsal, Abdulkadir; Koyuncu, Sümeyra; Gök, Mahmut; Öztürk, Savaş; ORUÇ, AYŞEGÜL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; AAH-4002-2021; CTG-8811-2022Purpose Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. Methods Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. Results Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). Conclusion This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.Publication Demographic and clinical characteristics of rapidly progressive glomerulonephritis in Turkey(Oxford Univ Press, 2020-06-01) Aydın, Zeki; Türkmen, Kultiğin; Dede, Fatih; Yaşar, Emre; Öztürk, Savaş; Tatar, Erhan; Şahin, Garip; Şahin, Gülizar Manga; Oto, Özgür Akın; Sumnu, Abdullah; Eroğlu, Eray; Dinçer, Mevlüt Tamer; Dursun, Belda; Eren, Necmi; Sevinç, Mustafa; Güzel, Fatma Betül; Yalın, Serkan Feyyaz; Kutlay, Sim; Apaydın, Süheyla; Berktaş, Hacı Bayram; Kazan, Sinan; Dheir, Hamad; Bora, Feyza; Baştürk, Taner; Şahin, İdris; Aydin, Mehmet; AYDIN, MEHMET AKİF; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-5665-7402; AAJ-8220-2020Publication Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group(Springer, 2020-09-29) Aydın, Zeki; Türkmen, Kültigin; Dede, Fatih; Yaşar, Emre; Öztürk, Savaş; Aydın, Mehmet; Tatar, Erhan; Şahin, Garip; Manga, Gülizar; Oto, Özgür; Şumnu, Abdullah; Eroğlu, Eray; Dinçer, Tamer; Dursun, Belda; Eren, Necmi; Sevinç, Mustafa; Güzel, Fatma Betül; Yalın, Serkan; Kutlay, Sim; Apaydın, Süheyla; Berktaş, Hacı Bayram; Kazan, Sinan; Dheir, Hamad; Bora, Feyza; Baştürk, Taner; Sahin, Idris; AYDIN, MEHMET AKİF; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Nefroloji Bilim Dalı.; 0000-0002-5665-7402; AAJ-8220-2020Background In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune). Results Of 3875 patients, 200 patients with RPGN (mean age 47.9 +/- 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9-5.7) mg/dl, glomerular filtration rate was 18 (10-37) ml/min/1.73m(2)and proteinuria 2100 (1229-3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusions Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.Publication Epidemiological and clinical characterstics of iga nephropathy patients in turkey: Tsn-gold working group(Oxford Univ Press, 2020-06-01) Eren, Necmi; Gürsu, Meltem; Cebeci, Egemen; Türkmen, Aydın; Yeter, Hasan Hacı; Seyahi, Nurhan; Pişkinpaşa, Serhan Vahit; Ersoy, Alpaslan; Baştürk, Taner; Şahin, Gülizar Manga; Yücel, Fatma Sibel Koçak; Genç, Ahmed Bilal; Şahin, Garip; Ulu, Memnune Sena; Soyhan, Merve; Türkmen, Kültigin; Özberk, Sümeyra; Elcioglu, Omer; Altunören, Orçun; Şahin, İdris; Kutlay, Sim; Ustündağ, Sedat; Kalender, Betül; Dede, Fatih; Altun, Bülent; Ersoy, Alpaslan; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021Publication Is the severity of glomerular igg staining in patient with iga nephropathy useful for predicting poor renal prognosis? The data from Tsn-gold working group(Oxford University Press, 2020-06-01) Turgutalp, Kenan; Cebeci, Egemen; Türkmen, Aydin; Derici, Ülver; Seyahi, Nurhan; Eren, Necmi; Dede, Fatih; Güllülü, Mustafa; Baştürk, Taner; Şahin, Gülizar Manga; Yılmaz, Mürvet; Sipahi, Savaş; Şahin, Garip; Ulu, Memnune Sena; Tatar, Erhan; Gündoğdu, Ali; Kazancıoğlu, Rümeyza Turan; Sevinç, Can; Güngör, Özkan; Şahin, İdris; Kutlay, Sim; Kurultak, İlhan; Aydın, Zeki; Altun, Bülent; Dursun, Belda; Yılmaz, Zülfikar; Uzun, Özcan; Süleymanlar, Gültekin; Candan, Ferhan; Sezer, Siren; Tanburoğlu, Derya Başak; Bahçebaşı, Zerrin Bicik; Taymez, Dilek Güven; Oygar, Deren; Akçalı, Esra; İstemihan, Zulal; Akçay, Ömer Faruk; Dinçer, Mevlüt Tamer; Ergül, Metin; Yenigün, Ezgi; Türkmen, Kültigin; Öztürk, Savaş; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; CTG-8811-2022Item Recurrent AA amyloidosis after renal transplantation: Effects on allograft survival(Oxford University, 2016-05) Sarıhan, İrem; Şenateş, Banu; Mirioğlu, Şafak; Seyahi, Nurhan; Baştürk, Taner; Altıparmak, Mehmet Rıza; Caliskan, Yaşar; Sever, Mehmet Şükrü; Yıldız, Abdülmecit; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı.; HIG-9032-2022Publication The importance of complement levels and clinical characteristics of primary membranoproliferative glomerulonephritis in Turkey(Oxford Univ Press, 2020-06-01) Tatar, Erhan; Oygar, Deren; Seyahi, Nurhan; Eren, Necmi; Cantürk, Yağmur; Güngor, Özkan; Derici, Ulver; Sipahioğlu, Murat; Sümnü, Abdullah; Odabaş, Ali Riza; Turgut, Didem; Çavdar, Caner; Şahin, Garip; Dursun, Belda; Taymez, Dilek Güven; Aydın, Fatma Yılmaz; Ulu, Memnune Sena; Baştürk, Taner; Yadigar, Serap; Bozacı, Ilter; Behlül, Ahmet; Sipahi, Savaş; Bahçebaşı, Zerrin Bicik; Karadag, Serhat; Yıldız, Abdulmecit; YILDIZ, ABDULMECİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi; HIG-9032-2022