Dizdar, Oğuzhan SıtkıGül, Cuma BülentGünal, Ali İhsanGundoğan, Kürşat2023-01-022023-01-022020-03-12Dizdar, O. S. vd. (2020). "The effect of hemodialysis, peritoneal dialysis and renal transplantation on nutritional status and serum micronutrient levels in patients with end-stage renal disease; Multicenter, 6-month period, longitudinal study". Journal of Trace Elements in Medicine and Biology, 60.0946-672Xhttps://doi.org/10.1016/j.jtemb.2020.126498https://www.sciencedirect.com/science/article/pii/S0946672X20300638http://hdl.handle.net/11452/30226Purpose: Nutritional status and micronutrient levels of end stage renal disease (ESRD) patients may vary depending on the mode of renal replacement therapy (RRT). We aimed to compare the effects of hemodialysis, peritoneal dialysis (PD) and renal transplantation (RT) on micronutrient levels and nutritional status in ESRD patients. Patients and Methods: A total of 77 ESRD patients who had not received RRT were included in this prospective longitudinal study. All ESRD patients underwent a blood serum analysis that assessed the micronutrients such as selenium, copper, zinc, chromium, retinol, thiamine and vitamin B6 as well as a nutritional status assessment. After the baseline assessments and the initiation of RRT was accomplished, all patients were followed for 6 months. Results: The study showed significant improvements in subjective global assessment scores (percentage increases in score A were 26.6 and 36.6; p= 0.039 and p= 0.001; respectively), mid-arm circumference and the skin-fold thicknesses (p < 0.001, p < 0.001; respectively) in the RT and hemodialysis groups. The examinations at sixth month revealed a significant increase in body weight (4.8 kg; p= 0.002) and albumin levels (0.6 g/dL; p < 0.001) in only RT group. Zinc, thiamin and vitamin B6 were the most deficient micronutrients (44.1 %, 24.7 % and 35.1 %; respectively) in ESRD patients. There was a significant increase in selenium and retinol levels (p= 0.020 and p < 0.001; respectively) but a significant decrease in thiamin levels (p= 0.041) in RT patients. A significant increase in retinol levels (p= 0.028) and a significant decrease in thiamin levels (p= 0.022) was observed in the hemodialysis patients. However, no significant change in micronutrient levels was observed in the PD patients. Conclusion: The results support the recommendation that ESRD patients should be supplemented with watersoluble vitamins, especially thiamine and vitamin B6, and trace elements, especially zinc. RT appears to be superior to other modes of RRT when examining SGA score, anthropometric measurements, albumin and micronutrient levels.eninfo:eu-repo/semantics/closedAccessRenal replacement therapyVitaminMineralNutritional assessmentAlbuminQuality-of-lifeTrace-elementsOxidative stressVitaminsPlasmaInflammationParametersMortalityRiskZincBiochemistry & molecular biologyEndocrinology & metabolismAdultFemaleHumansKidney failure, chronicKidney transplantationLongitudinal studiesMaleMicronutrientsMiddle agedNutritional statusProspective studiesRenal dialysisArticle0005244144000162-s2.0-850821274216032220765Biochemistry & molecular biologyEndocrinology & metabolismHemodialysis; Oxidative Stress; Chronic Kidney FailureAlbuminAzathioprineC reactive proteinChromiumCopperCyclosporineEverolimusMycophenolate mofetilPrednisolonePyridoxineRapamycinRetinolSeleniumTacrolimusThiamineTrace elementZincTrace elementAdultAlbumin blood levelArm circumferenceArticleBlood analysisBlood samplingBody weightChromium blood levelClinical effectivenessClinical trialCopper blood levelEnd stage renal diseaseFemaleHemodialysisHigh performance liquid chromatographyHumanImmunosuppressive treatmentKidney transplantationLongitudinal studyMajor clinical studyMaleMulticenter studyNutritional assessmentNutritional statusNutritional valueObservational studyPeritoneal dialysisPriority journalProspective studyProtein blood levelSelenium blood levelSkinfold thicknessTertiary care centerVitamin blood levelZinc blood levelBloodChronic kidney failureMiddle aged