2024-03-282024-03-282018Poroy, C. ve Yücel, A. A. (2018). ''Optical coherence tomography: Is really a new biomarker for alzheimer's disease?''. Annals of Indian Academy of Neurology, 21(2), 119-125.0972-2327https://journals.lww.com/annalsofian/fulltext/2018/21020/optical_coherence_tomography__is_really_a_new.5.aspxhttps://hdl.handle.net/11452/40645Introduction: Retinal ganglion cell (RGC) degeneration was histopathologically proved previously in Alzheimer's disease (AD) patients. In this study, we aimed to determine RGC degeneration in vivo using optical coherence tomography (OCT) in AD. Methods: Twenty-one mild-to-moderate AD patients and 25 cognitively healthy age-matched controls were enrolled in this case-control prospective study. All participants underwent OCT examination to assess peripapillary retinal nerve fiber layer (RNFL) thickness, macular volume, and thickness. Results: Foveal thickness and volume were significantly higher in AD patients than controls (P = 0.023 and P = 0.024, respectively). Compared to controls, peripapillary RNFL and other macular region measurements of AD patients were not statistically different (for all P > 0.05). Discussion: Increased foveal thickness and volume can be associated with the pathological changes in the early stages of degeneration These results differ from previous studies, but still confirm retinal degeneration in AD. Conclusion: With further OCT studies on large populations, OCT will be in clinical use for early diagnosis of AD.eninfo:eu-repo/semantics/openAccessNeurosciences & neurologyAlzheimer's diseaseBiomarkerOptical coherence tomographyRetinal nerve fiber layerNerve-fiber layerMild cognitive impairmentGanglion-cell degenerationMouse modelRetinal degenerationThicknessPathologyDementiaAbnormalitiesDysfunctionArticle0004398573000052-s2.0-8505079336711912521230122836https://doi.org/10.4103/aian.AIAN_368_17Clinical neurologyNerve Fibers; Retinal; Optical Coherence TomographyBiological markerAgedAlzheimer diseaseArticleBiomicroscopyCataractClinical articleControlled studyEyeEye fundusFemaleGlaucomaHumanIntraocular pressureMacular degenerationMacular thicknessMaleOptical coherence tomographyRefraction errorRetinal nerve fiber layerRetinal nerve fiber layer thicknessSpectral domain optical coherence tomographyVisual acuity1998-3549