Öztürk, Esin IşıkGümüş, Canerİnecikli, Mehmet Fatih2022-08-252022-08-252014-10Cebeci, H. vd. (2014). "Assesment of perfusion in glial tumors with arterial spin labeling; comparison with dynamic susceptibility contrast method". European Journal of Radiology, 83(10), 1914-1919.0720-048X1872-7727https://doi.org/10.1016/j.ejrad.2014.07.002https://www.sciencedirect.com/science/article/pii/S0720048X14003544http://hdl.handle.net/11452/28364Purpose: Arterial spin labeling perfusion imaging (ASL-PI) is a non-invasive perfusion imaging method that can be used for evaluation and quantification of cerebral blood flow (CBF). Aim of our study was to evaluating the efficiency of ASL in histopathological grade estimation of glial tumors and comparing findings with dynamic susceptibility contrast perfusion imaging (DSC-PI) method. Methods: This study involved 33 patients (20 high-grade and 13 low-grade gliomas). Multiphase multislice pulsed ASL MRI sequence and a first-passage gadopentetate dimeglumine T2*-weighted gradient-echo single-shot echo-planar sequence were acquired for all the patients. For each patient, perfusion relative signal intensity (rSI), CBF and relative CBF (rCBF) on ASL-PI and relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) values on DSC-PI were determined. The relative signal intensity of each tumor was determined as the maximal SI within the tumor divided by SI within symetric region in the contralateral hemisphere on ASL-PI. rCBV and rCBF were calculated by deconvolution of an arterial input function. Relative values of the lesions were obtained by dividing the values to the normal appearing symmetric region on the contralateral hemisphere. For statistical analysis, Mann-Whitney ranksum test was carried out. Receiver operating characteristic curve (ROC) analysis was performed to assess the relationship between the rCBF-ASL, rSI-ASL, rCBV and rCBF ratios and grade of gliomas. Their cut-off values permitting best discrimination was calculated. The correlation between rCBV, rCBF, rSI-ASL and rCBF-ASL and glioma grade was assessed using Spearman correlation analysis. Results: There was a statistically significant difference between low and high-grade tumors for all parameters. Correlation analyses revealed significant positive correlations between rCBV and rCBF-ASL (r=0.81, p<0.001). However correlation between rCBF and rCBF-ASL was weaker (r=0.64, p<0.001). Conclusion: Arterial spin labeling is an employable imaging technique for evaluating tumor perfusion non-invasively and may be useful in differentiating high and low grade gliomas.eninfo:eu-repo/semantics/closedAccessGliomaDynamic susceptibility contrast perfusion imagingArterial spin labelingCerebral blood-volumeBrain-tumorsEnhanced MRImaging techniquesGliomasEchoMapsQuantificationDiagnosisUtilityRadiology, nuclear medicine & medical imagingAdolescentAdultAgedBlood volumeBrain neoplasmsCerebrovascular circulationContrast mediaFemaleGadolinium DTPAGliomaHumansMagnetic resonance imagingMaleMiddle agedSensitivity and specificitySpin labelsAssesment of perfusion in glial tumors with arterial spin labeling; comparison with dynamic susceptibility contrast methodArticle0003414170000312-s2.0-8502795008319141919831025087109Radiology, nuclear medicine & medical imagingBrain Circulation; Arterial Spin Labeling; Magnetic Resonance AngiographyGadolinium pentetate meglumineContrast mediumGadodiamideGadolinium pentetateSpin labelingAdolescentAdultAgedArterial spin labeling perfusion imagingArticleBrain blood flowBrain blood volumeCancer gradingClinical articleComparative studyCorrelation analysisEcho planar imagingFemaleGliomaHemisphereHistopathologyHumanMaleNuclear magnetic resonance imagingNuclear magnetic resonance scannerPriority journalRank sum testReceiver operating characteristicScintigraphySpin labelingBlood volumeBrain circulationBrain tumorDiagnostic useGliomaMiddle agedPathologyProceduresSensitivity and specificityVascularization