2022-03-142022-03-142008-09Arabul, M. vd. (2008). ''Effect of fluvastatin on serum prohepcidin levels in patients with end-stage renal disease''. Clinical Biochemistry, 41(13), 1055-1058.0009-9120https://doi.org/10.1016/j.clinbiochem.2008.05.010https://www.sciencedirect.com/science/article/pii/S0009912008002191http://hdl.handle.net/11452/24987Objectives: Anemia, low-grade inflammation and/or alterations in lipid metabolism are common findings in individuals with end-stage renal disease (ESRD) despite advances in dialysis treatment. Hepcidin, a key regulator of iron metabolism, may play an important role in the interdependence of inflammation and anemia in ESRD patients. Statins may reduce cardiovascular events in dialysis patients and have pleiotropic effects in addition to lowering total and low-density lipoprotein (LDL)-cholesterol. Design and methods: Because there is a paucity of data on the effect of statins on serum prohepcidin levels in dialysis patients, this 8-week study was conducted to test the effect of fluvastatin (80 mg/day, n = 22) compared with placebo (n = 18) on circulating scruin prohepcidin, a prohormone of hepcidin, and high-sensitive C-reactive protein (hs-CRP) in dyslipidemic ESRD patients with renal anemia. Results: Fluvastatin treatment decreased total cholesterol (P < 0.05), LDL-cholesterol (P < 0.01), hs-CRP (P < 0.05) and serum prohepcidin levels (P < 0.05) significantly. Conclusion: Our pilot data suggest that short-term statin treatment may exert a beneficial effect on serum prohepcidin levels in ESRD patients. The potential clinical benefits of statins on renal anemia need to be confirmed and expanded with an appropriately powered long-term study.eninfo:eu-repo/semantics/closedAccessMedical laboratory technologyAnemiaEnd-stage renal diseaseInflammationProhepcidinStatinsChronic kidney-diseaseIron-metabolismHepcidinInflammationAdultAntimicrobial cationic peptidesC-reactive proteinDyslipidemiasFatty acids, monounsaturatedFemaleHumansIndolesKidney failure, chronicLipidsMaleMiddle agedProtein precursorsRenal dialysisArticle0002588145000062-s2.0-4934909416710551058411318571502Medical laboratory technologyHepcidins; Metal Transporting Protein 1; Iron-Refractory Iron Deficiency AnemiaFluindostatinHepcidinLow density lipoprotein cholesterolProhepcidinUnclassified drugAdultAnemiaArticleCholesterol blood levelClinical articleControlled studyDialysisDisease durationDrug effectDyslipidemiaFemaleHumanKidney diseaseMalePriority jlournalProtein blood leve