Levendusky, Mark C.Millington, William R.2023-11-232023-11-232004-12-10Göktalay, G. vd. (2004). “Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception”. Brain Research , 1029(1), 124-130.0006-8993https://doi.org/10.1016/j.brainres.2004.09.029https://www.sciencedirect.com/science/article/pii/S0006899304015707http://hdl.handle.net/11452/34986This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocame (2%; 0.1, 0.3 or 1.0 mul) or muscimol (0.34 nmol; 0.5 mul) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals.eninfo:eu-repo/semantics/closedAccessNeurosciences and neurologyLateral hypothalamusVisceral nociceptionPainGABA receptorMuscimolCardiovascular regulationMidbrain periaqueductal grayAnterior hypothalamusEfferent projectionsFosAreaImmunoreactivityOrganizationStimulationNucleusNeuronsAnimalsBradycardiaCardiovascular physiologyGABA agonistsHomocysteineHypotensionHypothalamic area, lateralMaleMicroinjectionsMuscimolPainRatsRats, sprague-dawleyArticle0002254817000152-s2.0-77442378621241301029115533324NeurosciencesPeriaqueductal Gray; Animals; Escape ReactionAnimal experimentAnimal modelArticleBradycardiaCardiovascular functionControlled studyDrug effectEvoked somatosensory responseHypotensionHypothalamusMaleMicroinjectionNociceptionNonhumanPriority journalRat4 aminobutyric acid a receptor stimulating agentAcetic acidLidocaineMuscimol