2023-01-092023-01-092017-04-10Tezcan, G. vd. (2017). ''Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro''. Biomedicine and Pharmacotherapy, 90, 713-723.0753-3322https://doi.org/10.1016/j.biopha.2017.04.022https://www.sciencedirect.com/science/article/pii/S07533322173078131950-6007http://hdl.handle.net/11452/30340Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2 mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p = 0.0001, p < 0.001, p = 0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM.eninfo:eu-repo/semantics/closedAccessResearch & experimental medicinePharmacology & pharmacyAngiogenesisGlioblastoma cancer stem cellInvasionMMP2MMP9Olea europaea leaf extractVEGFAAntiangiogenic therapiesMesenchymal transitionAntioxidant activityOlive oilOleuropeinExpressionPolyphenolsGata6ProliferationMicrorna-153Angiogenesis inhibitorsBevacizumabCell lineTumorCell movementDrug synergismGlioblastomaHumansMatrix metalloproteinase 2Matrix metalloproteinase 9Neoplasm invasivenessNeoplastic stem cellsNeovascularization, pathologicOleaPlant extractsPlant leavesVascular endothelial growth factor AArticle0004024710000872-s2.0-850175693247137239028419967Medicine, research & experimentalPharmacology & pharmacyCancer Stem Cell; Insurance Markets; Operational RiskAngiogenesis inhibitorBevacizumabGelatinase AGelatinase BOlea europaea extractPlant extractUnclassified drugVasculotropin AAngiogenesis inhibitorBevacizumabGelatinase AGelatinase BPlant extractVasculotropin AAntiangiogenic activityArticleCancer inhibitionCancer stem cellCell invasionControlled studyDrug efficacyDrug potentiationGlioblastomaGlioblastoma cell lineHumanHuman cellIn vitro studyMigration inhibitionOlive treePlant leafPriority journalCancer stem cellCell motionChemistryDrug effectsDrug potentiationGlioblastomaMetabolismNeovascularization (pathology)Olive treePathologyPlant leafTumor cell lineTumor invasion