Suttorp, MeinolfMetzler, MarkusMillot, FredericShimada, HiroyukiBansal, DeepakKalwak, KrzysztofSedlacek, PetrBaruchel, AndreBiondi, AndreaHijiya, NobukoSchultz, Kirk R.Schrappe, Martin2023-09-252023-09-252018-12Suttorp, M. vd. (2018). ''Generic formulations of imatinib for treatment of Philadelphia chromosome-positive leukemia in pediatric patients''. Pediatric Blood and Cancer, 65(12).1545-50091545-5017https://doi.org/10.1002/pbc.27431https://onlinelibrary.wiley.com/doi/10.1002/pbc.27431http://hdl.handle.net/11452/34011Since the patent for imatinib has expired, the role of generic imatinib (GI) in the management of Philadelphia chromosome-positive (Ph+) leukemia in pediatric patients has had ongoing discussion. Some studies in adults demonstrated that equivalent doses of GI and branded imatinib (BI) result in comparable plasma concentrations and clinical efficacy. However, other studies found that GI users are more likely to stop imatinib, with intolerance and decreased persistence as the main causes. Economic factors also heavily influence GI selection. This article aims to review the present knowledge to support further discussion on the role of GI in the management of pediatric Ph+ leukemia.eninfo:eu-repo/semantics/closedAccessOncologyHematologyPediatricsGeneric medicationImatinib inhibitorPediatricPh plus leukemiaTyrosine kinaseChronic myeloid-leukemiaChronic myelogenous leukemiaFollow-upMesylateEfficacyChildrenTherapyGlivecSafetyTabletAntineoplastic agentsChildDrugs, genericFemaleHumansImatinib mesylateLeukemia, myelogenous, chronic, BCR-ABL positiveMaleProtein kinase inhibitorsArticle0004475566000612-s2.0-85052796606651230160364OncologyHematologyPediatricsImatinib; Chronic Myeloid Leukemia; Generic DrugGeneric drugImatinibAntineoplastic agentGeneric drugImatinibProtein kinase inhibitorArticleCancer chemotherapyCancer patientChildChildhood leukemiaComparative studyHrug efficacyHrug formulationHealth care organizationHumanPatient advocacyPediatric patientPharmacological parametersPhiladelphia chromosome positive cellPriority journalChronic myeloid leukemiaFemaleMale