Ayyıldız, Talat2024-02-132024-02-132014Ayyıldız, T. vd. (2014). "Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/ advanced stage gastric cancer". Asian Pacific Journal of Cancer Prevention, 15(11), 4711-4716.1513-7368http://koreascience.or.kr/article/JAKO201426636276089.pagehttps://hdl.handle.net/11452/39630Introduction: Adiponectin (ApN) is a complement C1q-related protein, mainly secreted from adipose tissue, that signals through ApN receptor1 (Adipo-R1) and ApN receptor 2 (Adipo-R2). Low serum ApN concentrations are associated with obesity-related malignancies. However, there are very few studies on any prognostic role of ApN receptors in gastric cancer. Objectives: The aim of this study is to investigate the relationship between AdipoR1/R2 expression and early/advanced stage gastric cancer in terms of clinicopathologic characteristics and survival. Materials and Methods: Eighteen patients with early and 39 with advanced stage gastric cancer who underwent surgical gastric resection were included in this study. Results: Adipo-R1 expression was low in 2 of the 18 patients with early stage gastric cancer (11.1%), while 4 had low Adipo-R2 expression (22.2%). In those with advanced stage gastric cancer, 7 of 39 had low Adipo-R1 expression (17.9%) and 16 had low Adipo-R2 expression (41%). Adipo-R2 expression was significantly higher (p=0.011) in moderately differentiated tumors when compared to well-differentiated tumors. While there was nearly a statistically significant relationship between TNM stage (T, tumor size; N, regional lymph node; M, whether distant metastases exist) and Adipo-R2 expression (p=0.054), there was no relationship between Adipo-R1/-R2 expression with tumor stage and survival. Conclusion: Adipo-R1/-R2 expression has no prognostic significance of in early/advanced stage gastric cancer.eninfo:eu-repo/semantics/openAccessAdipo R1SurvivaAdipo R2Gastric carcinomaAdiponectinPrognosisCirculating adiponectinCloningPlasma adiponectinCarcinomaProstate-cancerMetastasisBreast-cancerRiskCellGrowthOncologyFemaleGene expressionHumansMaleMiddle agedNeoplasm stagingPrognosisReceptors, adiponectinStomach neoplasmsArticle0003386349000532-s2.0-8490374576547114716151124969908https://doi.org/10.7314/APJCP.2014.15.11.4711OncologyLeptin Receptors; Adiponectin; ObesityCancer stagingFemaleGene expressionGeneticsHumanMaleMiddle agedPathologyProceduresPrognosisStomach tumorAdiponectin receptorAdipor1 protein, humanAdipor2 protein, human