Adilay, Huseyin UtkuKatar, SalimGüçlü, BülentAltun, ErenOzdek, RecepTiryaki, MehmetBekar, Ahmet2024-06-252024-06-252021-01-011019-5149https://doi.org/10.5137/1019-5149.JTN.32092-20.1https://hdl.handle.net/11452/42347AIM: To investigate the effects of different radiation doses on the development of the neural tube defect in chick embryos using computed tomography (CT), and assess its correlation with survivin and Bcl-2 expressions.MATERIAL and METHODS: A total of 150 chicken eggs were used and grouped into five categories. In Group 1 (n=30), the embryos were not exposed to radiation. In Group 2 (n=30), the embryos were irradiated using lung cancer screening chest CT protocol. In Groups 3 and 4 (n=30 each), the abdominopelvic and adult routine head CT protocols, respectively, were used to irradiate the embryos. In Group 5 (n=30), the embryos were irradiated using adult brain perfusion CT protocol. Subsequently, the embryos were examined under a stereomicroscope to assess the presence of neural tube developmental abnormalities. Moreover, immunohistochemical staining was performed to determine the survivin and Bcl-2 expression levels.RESULTS: The risk of developing neural tube defect increased with the amount of exposed radiation. Moreover, no significant correlation was observed between the survivin and Bcl-2 expression levels and the radiation dose.CONCLUSION: Overall, the results of this study indicate that the radiation from CT may cause neural tube defect in chicken embryos.eninfo:eu-repo/semantics/closedAccessBcl2Chicken embryoNeural tube defectRadiationSurvivinScience & technologyLife sciences & biomedicineClinical neurologySurgeryNeurosciences & neurologySurgeryArticle00063170950001826827331210.5137/1019-5149.JTN.32092-20.1