Cander, SonerGül, Bülent2024-02-202024-02-202015-10-01Gül, Ö. Ö. vd. (2015). "Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome". European Cytokine Network, 26(4), 73-78.https://doi.org/10.1684/ecn.2015.0370https://hdl.handle.net/11452/39872This study was designed to evaluate insulin resistance and plasma levels of visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome (PCOS). A total of 37 premenopausal PCOS patients with (n = 18, mean (SD) age: 27.5 (5.7 years) or without obesity (n = 19, mean (SD) age: 23.7 (3.1) years) and healthy volunteers (n = 18, mean (SD) age: 29.8 (4.1) years) were included in this study. Data on clinical characteristics, glycemic parameters and lipid parameters were recorded for each subject as were plasma visfatin and resistin levels. Mean (SD) HOMA-IR values were significantly higher in obese PCOS patients (3.4 (1.7)) compared with non-obese PCOS patients (2.0 (1.2), p<0.01) and controls (1.6 (0.8), p<0.01). No significant difference was noted between study groups in terms of plasma resistin (ng/mL) or visfatin (ng/mL) levels. There was no correlation between serum plasma visfatin (r = 0.127, p = 0.407) and resistin (r = -0.096, p = 0.544) levels and HOMA-IR. In conclusion, our findings revealed increased likelihood of metabolic and dyslipidemic manifestations in obese compared to non-obese PCOS patients, while no significant difference was noted in visfatin and resistin levels among PCOS patients in terms of co-morbid obesity and in comparison to controls.eninfo:eu-repo/semantics/closedAccessBiochemistry & molecular biologyCell biologyImmunologyPolycystic ovary syndromeInsulin resistanceVisfatinResistinObesityBeta-cell functionMetabolic syndromeAdipose-tissueSerum visfatinRisk-factorsWomenSensitivityGlucoseWeightAdiponectinAdultCase-control studiesCytokinesFemaleHumansInsulinInsulin resistanceLipidsNicotinamide phosphoribosyltransferaseObesityPolycystic ovary syndromeResistinYoung adultArticle0003718165000022-s2.0-84960455079737826426967765Biochemistry & molecular biologyCell biologyImmunologyOvary polycystic disease; Hyperandrogenism; Insulin resistanceAminotransferaseHigh density lipoprotein cholesterolLow density lipoprotein cholesterolNicotinamide phosphoribosyltransferaseResistinTriacylglycerolCytokineInsulinLipidNicotinamide phosphoribosyltransferaseNicotinamide phosphoribosyltransferase, humanResistinRETN protein, humanAdultAnovulationArticleBody massCholesterol blood levelClinical articleControlled studyDyslipidemiaEnzyme blood levelEnzyme immunoassayFemaleGlucose blood levelHip circumferenceHirsutismHumanHyperandrogenismInsulin resistanceLipid blood levelMenstrual cycleMenstruation disorderObesityOral glucose tolerance testOvary polycystic diseasePremenopauseSmokingWaist circumferenceWaist hip ratioWaist to height ratioYoung adultBloodCase control studyComplicationObesityOvary polycystic disease