2024-01-252024-01-252006Kahveci, N. vd. (2006). ''Effects of intracerebroventricularly-injected morphine on anxiety, memory retrieval and locomotor activity in rats: Involvement of vasopressinergic system and nitric oxide pathway''. Pharmacology Biochemistry and Behavior, 85(4), 859-867.0091-3057https://www.sciencedirect.com/science/article/pii/S0091305706003984https://hdl.handle.net/11452/39306Morphine has been shown to alter several behavioural processes. We aimed to investigate the effects of intracerebroventricular (i.c.v.) morphine on anxiety, memory retrieval and locomotor activity in rats and to elucidate the possible involvement of the vasopressinergic system and the nitric oxide (NO) pathway in these effects. Rats were pretreated with morphine (0.5, 5, 50 mu g/5 mu l; i.c.v.) or saline (5 mu l; i.c.v.) 30 min before the elevated plus maze test, the probe trial of the Morris water maze and the open field test. Morphine (5 mu g/5 mu l; i.c.v.) induced significant anxiolytic effects in the elevated plus maze. None of the doses of morphine produced any effects in the probe trial of the Morris water maze and the open field. Pretreatment with an arginine vasopressin (AVP) V-1 receptor antagonist (25, 125 ng/5 mu l; i.c.v.), an AVP V-2 receptor antagonist (25, 125 ng/5 mu l, i.c.v.), or L-NAME, an NO synthase inhibitor (5, 25 mu g/5 mu l; i.c.v.) 30 min before morphine significantly prevented the anxiolytic effects of morphine. These results suggest that i.c.v. morphine has significant anxiolytic effects, probably mediated by both vasopressinergic system and NO pathway, but has no effect on memory retrieval or locomotor activity, at least at the applied doses.eninfo:eu-repo/semantics/closedAccessBehavioral sciencesNeurosciences & neurologyPharmacology & pharmacyNitric oxideVasopressinLocomotor activityMemoryAnxietyMorphineBehaviorMiceMotor-activityPlace preferenceSocial recognitionConditioned rewardNucleus-accumbensMu-opioid receptorsDorsal periaqueductal grayElevated plus-mazeRattusSignal transductionReceptors, vasopressinRats, sprague-dawleyRatsNitric oxide synthaseNitric oxideNG-nitroarginine methyl esterMotor activityMorphineMemoryMaleInjections, intraventricularAvoidance learningAnxietyAnimalsArticle0002443657000232-s2.0-3384646245285986785417223187https://doi.org/10.1016/j.pbb.2006.11.023Pharmacology & pharmacyNeurosciencesBehavioral sciencesOxytocin; Atosiban; VasopressinsVasopressin V2 receptorVasopressin V1 receptorVasopressin receptor antagonistVasopressinSodium chlorideNitric oxide synthaseNitric oxideN(g) nitroarginine methyl esterMorphineArgipressin receptorTranquilizing activityRecallRatPriority journalOpen field testNonhumanMorris water maze testMaze testMaleLocomotionDrug effectControlled studyArticleAnxietyAnimal experimentAnimal behavior