Yılmaz, YusufEren, FatihÇolak, YaşarKurt, RamazanŞenateş, EbubekirTuncer, İlyasİmeryuz, Neşe2021-12-292021-12-292011-11-20Yılmaz, Y. vd. (2011). ''Serum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosis''. Clinica Chimica Acta, 412(23-24), 2296-2299.0009-8981https://doi.org/10.1016/j.cca.2011.08.025https://pubmed.ncbi.nlm.nih.gov/21888902/http://hdl.handle.net/11452/23731Background: Increased serum concentrations of pigment epithelium-derived factor (PEDF) have been linked to the metabolic syndrome in the general population. However, the relationship between serum PEDF and nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, remains unknown. Methods: We assayed serum PEDF levels in 156 patients with biopsy-proven NAFLD and 103 nonsteatotic control subjects who were matched for age and sex. The association between levels of PEDF and clinical, biochemical, and histological phenotypes was examined. Results: NAFLD patients had significantly higher serum PEDF levels (1.97 +/- 0.50 mu g/mL) than control subjects (1.51 +/- 0.49 mu g/mL, Student's t test, P<0.001). Multivariable-adjusted stepwise regression analysis showed that PEDF ([beta] = 0.32, t = 3.13, P = 0.002) and triglycerides ([beta] = 0.22, t = 2.23. P = 0.02) were, in the order they entered into the model, the main independent predictors of steatosis scores in our patients with NAFLD. Conclusions: Serum PEDF levels are significantly increased in patients with biopsy-proven NAFLD and are associated with liver steatosis independently of traditional risk factors.eninfo:eu-repo/semantics/closedAccessMedical laboratory technologyPigment epithelium-derived factorNonalcoholic fatty liver diseaseEnzyme-linked immunosorbent assaySteatosisEndothelial growth-factorFactor pedfMetabolic syndromeInsulin-resistanceAngiogenesisActivationCellsAdultBiopsyEye proteinsFatty liverFemaleHumansMaleMiddle agedMultivariate analysisNerve growth factorsReproducibility of resultsSerpinsArticle0002966861000472-s2.0-800536353782296229941223-2421888902Medical laboratory technologyPigment Epithelium-Derived Factor; Type 6 Osteogenesis Imperfecta; Angiogenesis InhibitorsAlanine aminotransferaseAspartate aminotransferaseC reactive proteinCholesterolLow density lipoprotein cholesterolPigment epithelium derived factorTriacylglycerolAdultArticleBody massClinical assessmentControlled studyDiastolic blood pressureDisease associationFatty liverFemaleHistopathologyHomeostasisHumanHhuman tissueInsulin resistanceLiver biopsyMajor clinical studyMaleMetabolic syndrome XNonalcoholic fatty liverPhenotypePriority journalProtein blood levelSystolic blood pressure